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Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway 期刊论文

编号：

f5cbb802-c35b-451e-93d1-b4fd076c9df6
作者：

Li, Lei#^[1,2,3]Huang, Wenxiang^[3,4];Wang, Shoukai^[3];Sun, Kecheng^[3];Zhang, Wenxue^[3];Ding, Yanmei^[3];Zhang, Le^[3];Tumen, Bayaer^[5];Ji, Lili(季莉莉)*^[1,2]Liu, Chang*^[3]
语种：

英文
期刊：

MOLECULES ISSN：1420-3049 2018 年 23 卷 8 期 ; AUG
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关键词：

Astragaloside IV anti-oxidation acetaminophen liver injury
摘要：

Acetaminophen (APAP) is a well-known antipyretic and analgesic drug. However, the accidental or intentional APAP overdose will induce liver injury and even acute liver failure. Astragaloside IV (AS-IV), a bioactive compound isolated from Astragali Radix, has been reported to have protective effects on the digestive and immune systems because of its anti-oxidant and anti-inflammatory properties. This study aims to observe whether AS-IV pretreatment provides protection against APAP-induced liver failure. The results of serum alanine/aspartate aminotransferases (ALT/AST) analysis, hepatic glutathione (GSH), and malondialdehyde (MDA) amounts, and liver superoxide dismutase (SOD) activity showed that AS-IV protected against APAP-induced hepatotoxicity. Liver histological observation further evidenced this protection provided by AS-IV. AS-IV was found to reverse the APAP-induced increased amounts of pro-inflammatory cytokines, including interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Western-blot analysis showed that AS-IV increased the transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2), and enhanced the expression of heme oxygenase 1 (HO-1) and reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H): quinone oxidoreductase 1 (NQO1) in the presence of APAP. AS-IV also decreased the expression of kelch-like ECH-associated protein-1 (Keap1). In conclusion, we demonstrated that AS-IV exerted a strong protection against APAP-induced hepatotoxicity by activating Nrf2 antioxidant signaling pathways.
推荐引用方式
GB/T 7714：

Li Lei,Huang Wenxiang,Wang Shoukai, et al. Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway [J].MOLECULES,2018,23(8).
APA：

Li Lei,Huang Wenxiang,Wang Shoukai,Sun Kecheng,&Liu Chang.(2018).Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway .MOLECULES,23(8).
MLA：

Li Lei, et al. "Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway" .MOLECULES 23,8(2018).
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