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Red blood cell beta-adrenergic receptors contribute to diet-induced energy expenditure by increasing O-2 supply 期刊论文

编号：

f54dff9d-db7a-41fb-9e3c-ff3f7edb32fb
作者：

Kim, Eun Ran#^[1,2]Fan, Shengjie(范圣洁)^[1,2,3]Akhmedov, Dmitry^[4];Sun, Kaiqi^[5];Lim, Hoyong^[1,2];O'Brien, William^[5];Xu, Yuanzhong^[1,2];Mangieri, Leandra R.^[1,2,6];Zhu, Yaming^[1,2];Lee, ChengChi^[5];Chung, Yeonseok^[1,2];Xia, Yang^[5];Xu, Yong^[7];Li, Feng^[8];Sun, Kai^[1,2];Berdeaux, Rebecca^[1,2,4];Tong, Qingchun*^[1,2,6]
语种：

English
期刊：

JCI INSIGHT ISSN：2379-3708 2017 年 2 卷 14 期 ; JUL 20
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摘要：

Diet-induced obesity (DIO) represents the major cause for the current obesity epidemic, but the mechanism underlying DIO is unclear. beta-Adrenergic receptors (beta-ARs) play a major role in sympathetic nervous system-mediated (SNS-mediated) diet-induced energy expenditure (EE). Rbc express abundant beta-ARs; however, a potential role for rbc in DIO remains untested. Here, we demonstrated that high-fat, high-caloric diet (HFD) feeding increased both EE and blood O-2 content, and the HFD-induced increases in blood O-2 level and in body weight gain were negatively correlated. Deficiency of beta-ARs in rbc reduced glycolysis and ATP levels, diminished HFD-induced increases in both blood O-2 content and EE, and resulted in DIO. Importantly, specific activation of cAMP signaling in rbc promoted HFD-induced EE and reduced HFD-induced tissue hypoxia independent of obesity. Both HFD and pharmacological activation cAMP signaling in rbc led to increased glycolysis and ATP levels. These results identify a previously unknown role for rbc beta-ARs in mediating the SNS action on HFD-induced EE by increasing O-2 supply, and they demonstrate that HFD-induced EE is limited by blood O-2 availability and can be augenmented by increased O-2 supply.
推荐引用方式
GB/T 7714：

Kim Eun Ran,Fan Shengjie,Akhmedov Dmitry, et al. Red blood cell beta-adrenergic receptors contribute to diet-induced energy expenditure by increasing O-2 supply [J].JCI INSIGHT,2017,2(14).
APA：

Kim Eun Ran,Fan Shengjie,Akhmedov Dmitry,Sun Kaiqi,&Tong Qingchun.(2017).Red blood cell beta-adrenergic receptors contribute to diet-induced energy expenditure by increasing O-2 supply .JCI INSIGHT,2(14).
MLA：

Kim Eun Ran, et al. "Red blood cell beta-adrenergic receptors contribute to diet-induced energy expenditure by increasing O-2 supply" .JCI INSIGHT 2,14(2017).
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