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Drug delivery systems for elemene, its main active ingredient beta-elemene, and its derivatives in cancer therapy 期刊论文

编号：

f0197121-0154-457a-87e1-67974aac9442
作者：

Zhai, Bingtao#^[1]Zeng, Yiying^[2,3,4,5]Zeng, Zhaowu*^[2,3,4]Zhang, Nana^[2,3,4];Li, Chenxi^[2,3,4];Zeng, Yijun^[2,3,4];You, Yu^[1];Wang, Shuling^[2,3,4];Chen, Xiabin^[2,3,4];Sui, Xinbing^[2,3,4];Xie, Tian*^[2,3,4]
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF NANOMEDICINE ISSN：1178-2013 2018 年 13 卷 (6279 - 6296)
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关键词：

beta-elemene pharmacokinetics drug delivery system derivative safety
摘要：

beta-elemene is a noncytotoxic Class II antitumor drug extracted from the traditional Chinese medicine Curcuma wenyujin Y. H. Chen et C. Ling. beta-elemene exerts its effects by inhibiting cell proliferation, arresting the cell cycle, inducing cell apoptosis, exerting antiangiogenesis and antimetastasis effects, reversing multiple-drug resistance (MDR), and enhancing the immune system. Elemene injection and oral emulsion have been used to treat various tumors, including cancer of the lung, liver, brain, breast, ovary, gastric, prostate, and other tissues, for >20 years. The safety of both elemene injection and oral emulsion in the clinic has been discussed. Recently, the secondary development of beta-elemene has attracted the attention of researchers and made great progress. On the one hand, studies have been carried out on liposome-based systems (including solid lipid nanoparticles [SLNs], nanostructured lipid carriers [NLCs], long-circulating liposomes, active targeting liposomes, and multidrug-loaded liposomes) and emulsion systems (including microemulsions, self-emulsion drug delivery systems [SEDDSs], and active targeting microemulsion) to solve the issues of poor solubility in water, low bioavailability, and severe phlebitis, as well as to improve antitumor efficacy. The pharmacokinetics of different drug delivery systems of beta-elemene are also summarized. On the other hand, a number of highly active anticancer beta-elemene derivatives have been obtained through modification of the structure of beta-elemene. This review focuses on the two drug delivery systems and derivatives of beta-elemene for cancer therapy.
推荐引用方式
GB/T 7714：

Zhai Bingtao,Zeng Yiying,Zeng Zhaowu, et al. Drug delivery systems for elemene, its main active ingredient beta-elemene, and its derivatives in cancer therapy [J].INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:6279-6296.
APA：

Zhai Bingtao,Zeng Yiying,Zeng Zhaowu,Zhang Nana,&Xie Tian.(2018).Drug delivery systems for elemene, its main active ingredient beta-elemene, and its derivatives in cancer therapy .INTERNATIONAL JOURNAL OF NANOMEDICINE,13:6279-6296.
MLA：

Zhai Bingtao, et al. "Drug delivery systems for elemene, its main active ingredient beta-elemene, and its derivatives in cancer therapy" .INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):6279-6296.
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