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Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population 期刊论文

编号：

d9362eed-f85b-45e5-8554-cb6a3052ea46
作者：

Shen, Fangyuan#^[1]Chen, Jiejun#^[2]Guo, Shicheng#^[3,4]Zhou, Yinghui^[1];Zheng, Yabiao^[1];Yang, Yajun^[3,4];Zhang, Junjie^[1];Wang, Xiaofeng^[3,4];Wang, Chenji^[1];Zhao, Dunmei^[1];Wang, Mengyun^[5,6];Zhu, Meiling^[5,6];Fan, Lixia^[1];Xiang, Jiaqing^[6,7];Xia, Yong(夏勇)^[8]Wei, Qingyi^[5,9];Jin, Li^[3,4];Wang, Jiucun*^[3,4]Wang, Minghua*^[1]
语种：

英文
期刊：

TUMOR BIOLOGY ISSN：1010-4283 2016 年 37 卷 4 期 (4777 - 4784) ; APR
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关键词：

ESCC susceptibility miR-196a2 miR-499 rs11614913 rs3746444
摘要：

Esophageal squamous cell carcinoma (ESCC) is the dominant type of esophageal cancer in the East Asian population. MicroRNAs (miRNAs) have been studied to play important roles in tumorigenesis. Single nucleotide polymorphisms (SNPs) in miRNA lead to the aberrant expression and structural alteration of miRNA and are hypothesized to be involved in tumorigenesis and cancer development. We conducted a population-based case-control study to evaluate the association between SNPs in miRNAs and ESCC risk in 1400 ESCC cases and 2185 matched controls. Four SNPs including miR-196a2 rs11614913, miR-146a rs2910164, miR-499 rs3746444, and miR-423 rs6505162 were selected with comprehensive collection strategy and genotyped using the SNaPshot Multiplex System. Odds ratio (OR) and 95 % confidence interval (95 % CI) were used to assess the strength of association. The CC genotype of miR-196a2 rs11614913 was significantly associated with an increased ESCC risk compared with the TT genotype (OR 1.11, 95 % CI 1.01-1.22, P 0.049) and the TT/TC genotypes (OR 1.09, 95 % CI 1.01-1.19, P 0.043). The association was more pronounced in non-drinkers in the recessive model (OR 1.13, 95 % CI 1.01-1.27, P 0.029). A significantly increased risk of ESCC associated with miR-499 rs3746444 polymorphism was evident among patients who never smoking and drinking. This study suggests that miR-196a2 rs11614913 and miR-499 rs3746444 are associated with an increased ESCC risk in a Chinese population.
推荐引用方式
GB/T 7714：

Shen Fangyuan,Chen Jiejun,Guo Shicheng, et al. Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population [J].TUMOR BIOLOGY,2016,37(4):4777-4784.
APA：

Shen Fangyuan,Chen Jiejun,Guo Shicheng,Zhou Yinghui,&Wang Minghua.(2016).Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population .TUMOR BIOLOGY,37(4):4777-4784.
MLA：

Shen Fangyuan, et al. "Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population" .TUMOR BIOLOGY 37,4(2016):4777-4784.
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