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STAT3 Signaling Pathway 期刊论文

编号：

d915fa5a-3d8d-470e-ac17-4712e3fb9a5d
作者：

Liu, Xuan(刘宣)#^[1]Ji, Qing(季青)#^[1]Ye, Naijing(叶乃菁)^[1]Sui, Hua(隋华)^[1]Zhou, Lihong(周利红)^[1]Zhu, Huirong(朱惠蓉)^[1]Fan, Zhongze^[2];Cai, Jianfeng^[3];Li, Qi(李琦)*^[1]
语种：

英文
期刊：

PLOS ONE ISSN：1932-6203 2015 年 10 卷 5 期 ; MAY 8
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摘要：

Berberin, extracted from Chinese herbal medicine Coptis chinensis, has been found to have anti-tumor activities. However, the underlying mechanisms have not been fully elucidated. Our current study demonstrated that berberin inhibited the in vitro and in vivo growth, migration/invasion of CRC cells, via attenuating the expression levels of COX-2/PGE(2), following by reducing the phosphorylation of JAK2 and STAT3, as well as the MMP-2/-9 expression. We further clarified that an increase of COX-2/PGE2 expression offset the repressive activity of Berberin on JAK2/STAT3 signaling, and a JAK2 inhibitor AZD1480 blocked the effect of COX-2/PGE(2) on MMP-2/-9 expression. In summary, Berberin inhibited CRC invasion and metastasis via down-regulation of COX-2/PGE(2)-JAK2/STAT3 signaling pathway.
推荐引用方式
GB/T 7714：

Liu Xuan,Ji Qing,Ye Naijing, et al. Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE(2) Mediated JAK2/STAT3 Signaling Pathway [J].PLOS ONE,2015,10(5).
APA：

Liu Xuan,Ji Qing,Ye Naijing,Sui Hua,&Li Qi.(2015).Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE(2) Mediated JAK2/STAT3 Signaling Pathway .PLOS ONE,10(5).
MLA：

Liu Xuan, et al. "Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE(2) Mediated JAK2/STAT3 Signaling Pathway" .PLOS ONE 10,5(2015).
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