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Huang Qi Decoction Prevents BDL-Induced Liver Fibrosis Through Inhibition of Notch Signaling Activation 期刊论文

编号：

d3f1ec50-20dd-4d55-8be2-b22bbf8bf5f7
作者：

Zhang, Xiao(张笑)#^[1,3,4]Xu, Ying^[1,3];Chen, JiaMei^[1,3];Liu, Cheng^[1,3];Du, GuangLi(都广礼)^[2]Zhang, Hua(张华)^[1,3]Chen, GaoFeng^[1,3];Jiang, ShiLi^[1,3];Liu, ChengHai(刘成海)^[1,3]Mu, YongPing(慕永平)*^[1,3]Liu, Ping(刘平)*^[1,2,3]
语种：

英文
期刊：

AMERICAN JOURNAL OF CHINESE MEDICINE ISSN：0192-415X 2017 年 45 卷 1 期 (85 - 104)
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关键词：

Liver Fibrosis Hepatic Progenitor Notch Signaling Pathway Bile Duct Ligation Huang Qi Decoction
摘要：

Notch signaling has been demonstrated to be involved in ductular reactions and fibrosis. Previous studies have shown that Huang Qi Decoction (HQD) can prevent the progression of cholestatic liver fibrosis (CLF). However, whether HQD affects the Notch signaling pathway is unclear. In this study, CLF was established by common bile duct ligation (BDL) in rats. At the end of the first week, the rats were randomly divided into a model group (i.e., BDL), an HQD group, and a sorafenib positive control group (SORA) and were treated for 3 weeks. Bile duct proliferation and liver fibrosis were determined by tissue staining. Activation of the Notch signaling pathway was evaluated by analyzing expressions of Notch-1, -2, -3, and -4, Jagged (JAG) 1, and Delta like (DLL)-1, -3, and -4. The results showed that HQD significantly reduced the deposition of collagen and the Hyp content of liver tissue and inhibited the activation of HSCs compared with the BDL group. In addition, HQD significantly decreased the protein and mRNA expressions of TGF-beta 1 and alpha-SMA. In contrast, HQD significantly enhanced expression of the Smad 7 protein. HQD also reduced biliary epithelial cell proliferation, and reduced the mRNA levels of CK7, CK8, CK18, SRY-related high mobility group-box gene (SOX) 9, epithelial cell adhesion molecule (EpCAM) and the positive areas of CK19 and OV6. In addition, the mRNA and protein expressions of Notch-3, -4, JAG1, and DLL-1, -3 were significantly reduced in the HQD compared to the BDL group. These results demonstrated that HQD may prevent biliary liver fibrosis through inhibition of the Notch signaling pathway, and it may be a potential treatment for cholestatic liver disease.
推荐引用方式
GB/T 7714：

Zhang Xiao,Xu Ying,Chen Jia-Mei, et al. Huang Qi Decoction Prevents BDL-Induced Liver Fibrosis Through Inhibition of Notch Signaling Activation [J].AMERICAN JOURNAL OF CHINESE MEDICINE,2017,45(1):85-104.
APA：

Zhang Xiao,Xu Ying,Chen Jia-Mei,Liu Cheng,&Liu Ping.(2017).Huang Qi Decoction Prevents BDL-Induced Liver Fibrosis Through Inhibition of Notch Signaling Activation .AMERICAN JOURNAL OF CHINESE MEDICINE,45(1):85-104.
MLA：

Zhang Xiao, et al. "Huang Qi Decoction Prevents BDL-Induced Liver Fibrosis Through Inhibition of Notch Signaling Activation" .AMERICAN JOURNAL OF CHINESE MEDICINE 45,1(2017):85-104.
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