Multidrug resistance occurs when a tumor develops resistance to multiple chemotherapeutic drugs, which may include antitumor drugs with different chemical structures and mechanisms. Multidrug resistance limits the treatment effects of antitumor drugs, and is the main cause of chemotherapy failure. Multidrug resistance is caused by numerous factors including changes in ATP-binding cassette transporters, target proteins, detoxification, deoxyribonucleic acid repair, drug metabolic enzymes, and signal pathways of apoptosis. Clinical research indicates that natural products have great potential to treat tumors and reverse multidrug resistance. Natural products, which often have multiple targets, could play an important role in tumor treatment, have beneficial effects on tumor inhibition, improve symptoms, reduce radiotherapy and chemotherapy side effects, enhance immunity, and prolong survival. Because natural products often have few adverse reactions and less drug resistance, the antitumor activities of natural products have attracted extensive research. We aimed to review the basic research and clinical application of natural products in the reversal of multidrug resistance.
[1]Univ Jiangsu, Sch Med, Zhenjiang, Peoples R China.
[2]Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Key Lab Liver & Kidney Dis, Shanghai 201203, Peoples R China.
[3]Tianjin Med Univ Canc Inst & Hosp, Tianjin, Peoples R China.
[4]Chinese Acad Med Sci, Canc Inst & Hosp, Beijing, Peoples R China.
[5]Acad Chinese Med Sci, Expt Res Ctr, Beijing, Peoples R China.
(8.0+极速模式)