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HuangQi Decoction Improves Renal Tubulointerstitial Fibrosis in Mice by Inhibiting the Up-Regulation of Wnt/beta-Catenin Signaling Pathway 期刊论文

编号：

bdd82d13-c2a1-4cea-94f0-3ccd4cd29ddd
作者：

Jiang, MingQian(江铭倩)#^[1]Wang, Li(王利)#^[2]Cao, Aili(曹爱丽)^[2]Zhao, Jie^[1];Chen, Xia^[1];Wang, Yunman^[1];Wang, Hao(王浩)^[1]Peng, Wen(彭文)*^[1,2]
语种：

英文
期刊：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY ISSN：1015-8987 2015 年 36 卷 2 期 (655 - 669) ; MAY
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关键词：

HuangQi decoction Wnt/beta-catenin signaling pathway UUO model Tubulointerstitial fibrosis
摘要：

Object: To explore the effects of HuangQi decoction on tubulointerstitial fibrosis in mice and the Wnt/beta-catenin signaling pathway. Methods: Unilateral ureteral obstruction (UUO) model was used. A total of 120 C57/BL mice were randomly divided into 6 groups, sham group, sham+ HuangQi decoction group (1.08 g/kg), UUO group, UUO+HuangQi decoction group (0.12, 0.36, 1.08 g/kg). Immunohistochemical analysis, RT-PCR and Western blot were employed to examine the proteins and genes related to the Wnt/beta-catenin signaling pathway. Results: In UUO mice models, expression levels of Wnt3,4, Frizzled4, LRP5,6, beta-catenin, LEE-1, TCF-1, Snail, MMP2,7 genes were positively correlated with the degree of renal tubulointerstitial fibrosis, while expression levels of GSK-3 beta, Axin, APC, CK1 were negatively correlated. HuangQi decoction could down-regulate expression levels of Wnt3,4, Frizzled4, LRP5,6, beta-catenin, LEF-1, TCF-1, Snail, Twist, MMP2,7 and up-regulate expression levels of GSK-beta, Axin, APC, CK1 and E-cadherin. Conclusion: HuangQi decoction could effectively inhibit the up-regulation of Wnt/beta-catenin signaling pathway induced by UUO, implying a possible role in improving renal interstitial fibrosis. Copyright (C) 2015 S. Karger AG, Basel
推荐引用方式
GB/T 7714：

Jiang Ming-Qian,Wang Li,Cao Ai-li, et al. HuangQi Decoction Improves Renal Tubulointerstitial Fibrosis in Mice by Inhibiting the Up-Regulation of Wnt/beta-Catenin Signaling Pathway [J].CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2015,36(2):655-669.
APA：

Jiang Ming-Qian,Wang Li,Cao Ai-li,Zhao Jie,&Peng Wen.(2015).HuangQi Decoction Improves Renal Tubulointerstitial Fibrosis in Mice by Inhibiting the Up-Regulation of Wnt/beta-Catenin Signaling Pathway .CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,36(2):655-669.
MLA：

Jiang Ming-Qian, et al. "HuangQi Decoction Improves Renal Tubulointerstitial Fibrosis in Mice by Inhibiting the Up-Regulation of Wnt/beta-Catenin Signaling Pathway" .CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 36,2(2015):655-669.
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