Objective To investigate the efficacy and safety of Tui Na for treating spasticity of the upper limbs of stroke patients. Design A prospective, multicenter, blinded, randomized controlled intervention study. Subjects Stroke patients with upper limb spasticity who were treated between December 2013 and February 2017 in 16 participating institutions in China were randomly assigned to receive either Tui Na plus conventional rehabilitation (Tui Na group, n = 222,) or conventional rehabilitation only (control group, n = 222). Methods Eligible adult patients (aged 18-75 years) were enrolled 1-12 months after stroke and randomly allocated in a 1:1 ratio to the two groups. Outcome assessors were blinded to treatment allocation. Muscle tone in the spastic muscles was evaluated using the Modified Ashworth Scale (MAS), and the primary endpoint was the change in MAS score over 4 weeks of treatment. Results Among patients who had experienced stroke 1-3 months before treatment, the Tui Na group experienced significantly greater reductions in MAS scores for three muscle groups than did the control group after 4 weeks of treatment. These improvements were sustained at the 3- and 6-month follow-ups. However, among patients who suffered from stroke 4-6 months and 7-12 months before treatment, the change in MAS with treatment did not differ significantly between those who did and those who did not receive Tui Na. No Tui Na-related adverse events during treatment were reported the groups. Conclusion Tui Na was effective and safe for alleviating poststroke spasticity within 1-3 months after stroke onset.
[1]Nanjing Med Univ, Rehabil Med Dept, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China.
[2]Nanjing Univ Chinese Med, Clin Med Sch 2, Nanjing, Jiangsu, Peoples R China.
[3]Nanjing Med Univ, Teaching & Res Dept Stat, Nanjing, Jiangsu, Peoples R China.
[4]HaiNan Med Univ, Rehabil Ctr, Affiliated Hosp 2, Haikou, Hainan, Peoples R China.
[5]Henan Univ Tradit Chinese Med, Rehabil Dept, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China.
[6]Jiangsu Prov Hosp Tradit Chinese Med, Acupuncture Rehabil Dept, Nanjing, Jiangsu, Peoples R China.
[7]Heilongjiang Univ Chinese Med, Rehabil Ctr, Affiliated Hosp 2, Haerbin, Heilongjiang, Peoples R China.
[8]Guangdong Prov Tradit Chinese Med Hosp, Rehabil Dept, Guangzhou, Guangdong, Peoples R China.
[9]Huazhong Univ Sci & Technol, Rehabil Dept, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
[10]Shanghai Univ Tradit Chinese Med, Neurol Rehabil Dept, Shanghai, Peoples R China.
[11]Xuzhou Cent Hosp, Rehabil Ctr, Xuzhou, Jiangsu, Peoples R China.
[12]Xuzhou Med Univ, Rehabil Dept, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China.
[13]Tianjin Med Univ, Rehabil Dept, Gen Hosp, Tianjin, Peoples R China.
[14]Nanjing Hosp Tradit Chinese Med, Neurol Dept, Nanjing, Jiangsu, Peoples R China.
[15]Hubei Prov Hosp Integrated Chinese & Western Med, Rehabil Dept, Wuhan, Hubei, Peoples R China.
[16]Lianyungang Chinese Med Hosp, Rehabil Dept, Lianyungang, Peoples R China.
[17]Dongguan Kanghua Hosp, Rehabil Dept, Dongguan, Peoples R China.
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