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Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma 期刊论文

编号：

bb3a6e90-01a2-4eb8-8d3b-0bebf636cfe4
作者：

Guo, Wei#^[1]Sun, YunFan#^[2,3]Shen, MinNa#^[1]Ma, XiaoLu^[1];Wu, Jiong^[1];Zhang, ChunYan^[1];Zhou, Yan^[1];Xu, Yang^[2,3];Hu, Bo^[2,3];Zhang, Min^[4];Wang, Gang^[4];Chen, WeiQin(陈伟琴)^[5]Guo, Lin^[6];Lu, RenQuan^[6];Zhou, ChaoHui^[7];Zhang, Xin^[2,3];Shi, YingHong^[2,3];Qiu, ShuangJian^[2,3];Pan, Baishen^[1];Cao, Ya^[8,9];Zhou, Jian^[2,3,10];Yang, XinRong*^[2,3]Fan, Jia*^[2,3,10]
语种：

英文
期刊：

CLINICAL CANCER RESEARCH ISSN：1078-0432 2018 年 24 卷 9 期 (2203 - 2213) ; MAY 1
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摘要：

Background: In the present study, we assessed the clinical value of circulating tumor cells (CTC) with stem-like phenotypes for diagnosis, prognosis, and surveillance in hepatitis B virus (HBV)related hepatocellular carcinoma (HCC) by an optimized qPCR-based detection platform.
Methods: Differing subsets of CTCs were investigated, and a multimarker diagnostic CTC panel was constructed in a multicenter patient study with independent validation (total n = 1,006), including healthy individuals and patients with chronic hepatitis B infection (CHB), liver cirrhosis (LC), benign hepatic lesion (BHL), and HBV-related HCC, with area under the receiver operating characteristic curve (AUC-ROC) reflecting diagnostic accuracy. The role of the CTC panel in treatment response surveillance and its prognostic significance were further investigated.
Results: The AUC of the CTC panel was 0.88 in the training set [sensitivity = 72.5%, specificity = 95.0%, positive predictive value (PPV) = 92.4, negative predictive value (NPV) = 77.8] and 0.93 in the validation set (sensitivity = 82.1%, specificity = 94.2%, PPV = 89.9, NPV = 89.3). This panel performed equally well in detecting early-stage and a-fetoprotein-negative HCC, as well as differentiating HCC from CHB, LC, and BHL. The CTC load was decreased significantly after tumor resection, and patients with persistently high CTC load showed a propensity of tumor recurrence after surgery. The prognostic significance of the CTC panel in predicting tumor recurrence was further confirmed [training: HR = 2.692; 95% confidence interval (CI), 1.617-4.483; P < 0.001; and validation: HR = 3.127; 95% CI, 1.360-7.190; P = 0.007].
Conclusions: Our CTC panel showed high sensitivity and specificity in HCC diagnosis and could be a real-time parameter for risk prediction and treatment monitoring, enabling early decision-making to tailor effective antitumor strategies. (C) 2018 AACR.
推荐引用方式
GB/T 7714：

Guo Wei,Sun Yun-Fan,Shen Min-Na, et al. Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma [J].CLINICAL CANCER RESEARCH,2018,24(9):2203-2213.
APA：

Guo Wei,Sun Yun-Fan,Shen Min-Na,Ma Xiao-Lu,&Fan Jia.(2018).Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma .CLINICAL CANCER RESEARCH,24(9):2203-2213.
MLA：

Guo Wei, et al. "Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma" .CLINICAL CANCER RESEARCH 24,9(2018):2203-2213.
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