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Xiyanping injection therapy for children with mild hand foot and mouth disease: a randomized controlled trial 期刊论文

编号：

b4ff754a-4baf-4268-bbc0-595ef9b35118
作者：

Zhang Guoliang#*^[1]He Liyun^[2];Tang Liuping^[3];Yang Tong^[4];Zou Xinying^[5];Zhu Qingxiong^[6];Yan Shiyan^[7];Hou Yong^[1];Huang Baoju^[8];Zhao Jindong^[9];Li Yan^[1];Huang Jihan(黄继汉)^[10]
语种：

英文
期刊：

JOURNAL OF TRADITIONAL CHINESE MEDICINE ISSN：0255-2922 2017 年 37 卷 3 期 (397 - 403) ; JUN 15
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关键词：

Hand foot and mouth disease Anti-pyretics Body temperature regulation Xiyanping injection Randomized controlled trial
摘要：

OBJECTIVE: To evaluate the clinical effects of Xiyan-ping injection intervention in pediatric patients with mild hand foot and mouth disease (HFMD).
METHODS: A total of 329 patients were stratified and block-randomized for symptomatic treatment of HFMD and assigned to, one of the following groups: Western Medicine (group A, n = 103), Xiyan-ping injection (group B, n = 109), or Xiyanping injection and symptomatic treatment using Western Medicine (group C, n = 117). During the trial, fever, rash, ulcers of the mouth were observed among participants in each group before and after treatment, and conversion rates from mild to severe HFMD were measured.
RESULTS: After 3-7 days' treatment, no significant differences in the conversion rates from mild to severe HFMD were observed among the three groups (P > 0.05). There was a significantly low number of patients with the onset time of antifebrile effect, vanished time of hand and foot rashes and cumulative time for the ulcers in the mouth vanished, among the three groups (P < 0.05, P < 0.01). The onset time of antifebrile effect of patients in groups B and C were markedly shorter compared with those in group A (P < 0.05, P < 0.01); there was no statically significant difference observed between groups B and C (P > 0.05). No significant differences were observed in the time for body temperature recovery among the three groups (P > 0.05). There were no significant differences in adverse effects among the three groups (P > 0.05).
CONCLUSION: Xiyanping injection together with use of Western Medicine is most effective for symptomatic treatment of mild HFMD. No severe adverse reactions were observed.
推荐引用方式
GB/T 7714：

Zhang Guoliang,He Liyun,Tang Liuping, et al. Xiyanping injection therapy for children with mild hand foot and mouth disease: a randomized controlled trial [J].JOURNAL OF TRADITIONAL CHINESE MEDICINE,2017,37(3):397-403.
APA：

Zhang Guoliang,He Liyun,Tang Liuping,Yang Tong,&Huang Jihan.(2017).Xiyanping injection therapy for children with mild hand foot and mouth disease: a randomized controlled trial .JOURNAL OF TRADITIONAL CHINESE MEDICINE,37(3):397-403.
MLA：

Zhang Guoliang, et al. "Xiyanping injection therapy for children with mild hand foot and mouth disease: a randomized controlled trial" .JOURNAL OF TRADITIONAL CHINESE MEDICINE 37,3(2017):397-403.
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