首页 / 院系成果 / 成果详情页

Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts 期刊论文

编号：

b10631ab-1b86-40d0-86fd-0ab4f9a2bbc5
作者：

Xu, Xiaowen#^[1,2]Zhu, Li^[3];Yang, Yun^[4];Pan, Yamin(潘亚敏)^[1]Feng, Zhuo^[1];Li, Ye^[1];Chang, Wenjun*^[5]Sui, Jinke*^[2]Cao, Fuao*^[2]
语种：

英文
期刊：

BRITISH JOURNAL OF CANCER ISSN：0007-0920 2019 年 120 卷 10 期 (987 - 995) ; MAY 14
收录：
摘要：

BACKGROUND: Vimentin (VIM) is considered a prognostic marker in colorectal cancer (CRC). Our aim is to identify genes that fulfil a "X-low implies VIM-high" Boolean relationship and to evaluate their prognostic value and potential mechanism.
METHODS: Potential biomarkers related to VIM expression were searched using a bioinformatics approach across gene-expression arrays. Based on subgroup analysis of 2 CRC cohorts, the selected gene was tested for its association with patient's survival outcomes. The regulatory link between the selected gene and VIM was further examined with in vitro models.
RESULTS: PPM1H was identified as the top candidate in our search. Patients with PPM1H-low tumours have a lower 5-year disease-free survival rate than patients with PPM1H-high tumours in 2 independent cohorts. In multivariate Cox analysis, patients with PPM1H-low tumours were independently associated with relapse in both the discovery cohort (hazard ratio [HR], 1.362; 95% confidence interval [CI], 1.015-1.826; P = 0.039) and the validation cohort (HR for DFS, 4.052; 95% CI, 2.634-6.234; P < 0.001). PPM1H knockdown in CRC cells and growth in the corresponding conditional medium increased VIM expression and colon fibroblast proliferation, indicating a transformation of cancer-association fibroblasts (CAFs). Conversely, educated CAFs also facilitated the growth of CRC cells with low PPM1H expression.
CONCLUSIONS: Lack of tumour PPM1H expression identifies a patient subgroup with a high relapse risk, and CRC cells with low expression of PPM1H activate CAFs and inversely get promoted by CAFs.
推荐引用方式
GB/T 7714：

Xu Xiaowen,Zhu Li,Yang Yun, et al. Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts [J].BRITISH JOURNAL OF CANCER,2019,120(10):987-995.
APA：

Xu Xiaowen,Zhu Li,Yang Yun,Pan Yamin,&Cao Fuao.(2019).Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts .BRITISH JOURNAL OF CANCER,120(10):987-995.
MLA：

Xu Xiaowen, et al. "Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts" .BRITISH JOURNAL OF CANCER 120,10(2019):987-995.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：96  下载次数：0

分享到：

浏览次数：96

下载次数：0

打印次数：0