首页 / 院系成果 / 成果详情页

Shexiang Tongxin dropping pill attenuates atherosclerotic lesions in ApoE deficient mouse model 期刊论文

编号：

ad83c149-b826-423f-9d6a-501d348bdcdd
作者：

Xiong, Minqi(熊敏琪)#^[1]Jia, Chenglin(贾成林)#^[1]Cui, Jingang^[1,2];Wang, Peiwei^[1,2];Du, Xiaoye^[1,2];Yang, Qinbo^[1,2];Zhu, Yuling^[4];Wang, Wenjian^[2,3];Zhang, Teng(张腾)*^[1,2]Chen, Yu(陈瑜)^[1,2]
语种：

英文
期刊：

JOURNAL OF ETHNOPHARMACOLOGY ISSN：0378-8741 2015 年 159 卷 (84 - 92) ; JAN 15
收录：
关键词：

Shexiang Tongxin dropping pill Atherosclerosis Inflammation Oxidative stress microRNA
摘要：

Ethnopharmacological relevance: Shexiang Tongxin dropping pill (STDP) is a formulation of Traditional Chinese Medicine mainly used for clinical treatment of stable angina pectoris in China.
Aim of the study: To investigate the effects and mechanisms of STOP treatment on atherosclerosis.
Materials and methods: ApoE deficient (ApoE(-/-)) mice were utilized to evaluate the effect of STDP treatment (30 mg/kg/day) on atherosclerotic lesions. Histopathological features of atherosclerotic lesions, serum levels of lipid proteins, parameters of oxidative stress and pro-inflammatory cytokines were measured by H&E staining, Masson's trichrome staining and ELISA, respectively. Real-time PCR analyses were performed to examine the aortic expression of atherosclerosis-associated microRNAs.
Results: The STDP treatment resulted in attenuated atherosclerotic lesion manifested by reduced lipid deposition, fibrosis and oxidative stress. It also led to increase in serum levels of GSH and SOD, decrease in MDA, decrease in CHO, TG, LDL, ox-LDL and increase in HDL, respectively. Additionally, the levels of pro-inflammatory cytokines including IL-2, IL-6, TNF-alpha and gamma-IFN were markedly reduced by STOP treatment. Furthermore, STDP treatment was associated with a significant reduction in the aortic expression of miR-21a, miR-132, miR-126a, miR-155 and increased expression of miR-20a.
Conclusion: Our results demonstrated for the first time that STOP attenuated atherosclerotic lesions in ApoE-/- mouse model. Moreover, STDP treatment exhibited multi-targeting effects on pathological, biochemical and molecular aspects of atherosclerosis implicating lipid regulation, fibrosis, inflammation and oxidative stress. Findings from the current study warrant further evaluation of the clinical application of STOP in atherosclerosis treatment. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Xiong Minqi,Jia Chenglin,Cui Jingang, et al. Shexiang Tongxin dropping pill attenuates atherosclerotic lesions in ApoE deficient mouse model [J].JOURNAL OF ETHNOPHARMACOLOGY,2015,159:84-92.
APA：

Xiong Minqi,Jia Chenglin,Cui Jingang,Wang Peiwei,&Chen Yu.(2015).Shexiang Tongxin dropping pill attenuates atherosclerotic lesions in ApoE deficient mouse model .JOURNAL OF ETHNOPHARMACOLOGY,159:84-92.
MLA：

Xiong Minqi, et al. "Shexiang Tongxin dropping pill attenuates atherosclerotic lesions in ApoE deficient mouse model" .JOURNAL OF ETHNOPHARMACOLOGY 159(2015):84-92.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：51  下载次数：0

分享到：

浏览次数：51

下载次数：0

打印次数：0