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Astragaloside IV Inhibits Adipose Lipolysis and Reduces Hepatic Glucose Production via Akt Dependent PDE3B Expression in HFD-Fed Mice 期刊论文

编号：

a936f150-dcac-4afc-981b-c4789a5c4a4d
作者：

Du, Qun#^[1]Zhang, Shuihong^[2];Li, Aiyun^[3]Mohammad, Imran S.^[4];Liu, Baolin^[2];Li, Yanwu*^[1]
语种：

英文
期刊：

FRONTIERS IN PHYSIOLOGY ISSN：1664-042X 2018 年 9 卷 ; JAN 23
收录：
关键词：

astragaloside IV Akt PDE3B lipolysis gluconeogenesis
摘要：

Objective: This study aims to investigate the effect of astragaloside IV on adipose lipolysis and hepatic gluconeogenesis.
Methods: High-fat diet (HFD) feeding induced adipose dysfunction with enhanced endogenous glucose production in mice. The effects of Astragaloside IV on lipolysis and hepatic glucose production were investigated.
Results: HFD feeding induced cAMP accumulation through reducing PDE3B expression and activity in adipose tissue. As a result, HFD feeding increased adipose lipolysis in mice. Astragaloside IV enhanced Akt phosphorylation and promoted Akt binding to PDE3B to preserve PDE3B content, resultantly reducing adipose cAMP accumulation. Knockdown of Akt1/2 diminished the effect of astragaloside IV on PDE3B induction, indicative of the role of Akt in astragaloside IV action. As a result from blocking of cAMP/PKA signaling, astragaloside IV suppressed hormone-sensitive lipase (HSL) activation and inhibited inflammation-associated adipose lipolysis. Moreover, astragaloside IV reduced ectopic fat deposition in the liver and inhibited FoxO1 activation via regulation of Akt, resultantly restraining excess hepatic glucose production.
Conclusion: We showed that preserving PDE3B content by Akt is a key regulation to prevent lipolysis. Astragaloside IV inhibited lipolysis by reducing cAMP accumulation via regulation of Akt/PDE3B, contributing to limiting hepatic lipid deposition and restraining excessive hepatic glucose production.
推荐引用方式
GB/T 7714：

Du Qun,Zhang Shuihong,Li Aiyun, et al. Astragaloside IV Inhibits Adipose Lipolysis and Reduces Hepatic Glucose Production via Akt Dependent PDE3B Expression in HFD-Fed Mice [J].FRONTIERS IN PHYSIOLOGY,2018,9.
APA：

Du Qun,Zhang Shuihong,Li Aiyun,Mohammad Imran S.,&Li Yanwu.(2018).Astragaloside IV Inhibits Adipose Lipolysis and Reduces Hepatic Glucose Production via Akt Dependent PDE3B Expression in HFD-Fed Mice .FRONTIERS IN PHYSIOLOGY,9.
MLA：

Du Qun, et al. "Astragaloside IV Inhibits Adipose Lipolysis and Reduces Hepatic Glucose Production via Akt Dependent PDE3B Expression in HFD-Fed Mice" .FRONTIERS IN PHYSIOLOGY 9(2018).
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