In this study, a new type of mixed micelles was developed using Soluplus (SOL) and Pluronic P105 (P105) for the encapsulation of Oridonin (ORN). Oridonin-loaded micelles (ORN-M) were simply prepared using solvent evaporation and characterized for particle size, particle morphology, encapsulation efficiency, and drug loading. In addition, the in vitro drug release behavior of ORN-M was assessed using the widely applied dialysis bag technique. The pharmacokinetic property of ORN was explored in rats after oral administration of ORN-M. Optimized ORN-M were of a small size (137.2 +/- 1.65 nm) and spherical shape when the ratio of SOL:P105 was 3:1, with entrapment efficiency 90.48 +/- 1.85% and drug loading 15.08 +/- 0.38%. Oral absorption capacity of ORN was greatly enhanced with a relative bioavailability of 210.55% in comparison to that of in-house suspensions, which suggests that ORN-M shows significantly improved bioavailability and drug absorption characteristics. Overall, the optimized SOL-P105 dual mixed micelles show great potential for use as oral drug carriers for cancer treatment. (C) 2016 Published by Elsevier B.V.
[1]Nanjing Univ Chinese Med, Nanjing 210023, Jiangsu, Peoples R China.
[2]Huangshan Univ, Coll Chem & Chem Engn, Huangshan 245041, Anhui, Peoples R China.
[3]Jiangsu Prov Acad Chinese Med, Key Lab New Drug Delivery Syst Chinese Mat Med, Nanjing 210028, Jiangsu, Peoples R China.
[4]Shanghai Univ Tradit Chinese Med, Engn Res Ctr Modern Preparat Technol TCM, Minist Educ, Shanghai 200000, Peoples R China.
(8.0+极速模式)