Objective: To explore the clinical efficacy of total knee arthroplasty (TKA) surgery in the treatment of rheumatic arthritis of elderly. Methods: A total of 98 elderly patients with rheumatic arthritis who underwent TKA surgery in our hospital from June 2015 to July 2017 were retrospectively studied. The conditions of the patients were recorded before and after surgery, and a follow-up visit was conducted at 3-24 months (average of 13.0 +/- 2.4 months) after surgery. Hospital for special surgery (HSS) scores, range of motion (ROM) of the knee joint and visual analog scale (VAS) pain scores were used to evaluate the knee joint function before and after surgery, and observe whether there were complications. A 36-item short-form (SF-36) health survey was adopted to assess the patients' quality of life. Results: After final follow-up visit, HSS scores of knee joint of the 98 patients were increased from 44.312 +/- 6.225 points before surgery to 89.164 +/- 7.194 points after surgery (P=0.000). The excellent and good rate was 88.776%. The ROM of knee joint was improved obviously at the final follow-up visit compared with that before surgery. It was increased from 43.609 +/- 2.816 degrees before surgery to 103.097 +/- 4.318 degrees after surgery (P=0.000). The VAS scores of the patients after final follow-up visit were 2.164 +/- 0.452 points, which were significantly lower than those before surgery (7.130 +/- 1.223 points, P=0.000). The patients' three characterization values of phlebothrombosis were reduced at the follow-up visit after surgery, among which the fibrinogen was decreased to the normal range. The total incidence rate of complications was 30.612%. The patients' quality of life after surgery was remarkably higher than that before surgery. The difference was statistically significant (P=0.000). Conclusion: Artificial TKA surgery can effectively improve ROM of the knee joint, reduce the pain and improve the quality of life for the patients. It has a good clinical efficacy for the treatment of elderly rheumatic arthritis.