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Effect of Shuanghu Qinggan Granule () and Yigan Yiqi Jieyu Granule () plus lamivudine on chronic hepatitis B patients: A randomized double-blind placebo-controlled trial. 期刊论文

编号：

a6a93b30-48be-4c1c-b2a6-d2b12c4b9604
作者：

Ye YongAn^[1];Tian DeLu^[2];Jiang Jian^[3];Li Jun^[4];Chen JianJie(陈建杰)^[3]Li ZhiHong^[2];Ma WeiGuo^[2];Zhao YiMing^[5];Wang RongBing^[6];Yang ShiZhong^[7];Shao FengZhen^[8];Ji Guang(季光)^[9]Zhou DaQiao^[10];Liu TieJun^[7];Cheng DongSheng^[11];Zhang Wei^[9];Sun KeWei^[12];Wang YuFen^[2];Min LeQuan^[13];Li XiaoKe^[2];
地址：

[1]Department of Gastroenterology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China. Yeyongan@vip.163.com.
[2]Department of Gastroenterology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China.
[3]Department of Hepatology, Shanghai Shuguang Hospital, Shanghai, 201210, China.
[4]Department of Integrated Chinese and Western Medicine, 302 Military Hospital of China, Beijing, 100039, China.
[5]Epidemic Research Center, The Third Hospital Affiliated to Peking University, Beijing, 100191, China.
[6]Department of Integrated Chinese and Western Medicine, Beijing Ditan Hospital, Beijing, 100015, China.
[7]Department of Hepatology, Hospital Affiliated to Changchun University of Chinese Medicine, Changchun, 130021, China.
[8]Department of Hepatology, The First Hospital Affiliated to Tianjin University of Chinese Medicine, Tianjin, 300193, China.
[9]Department of Hepatology, Shanghai Longhua Hospital, Shanghai, 200032, China.
[10]Department of Hepatology, Shenzhen Hospital of Chinese Medicine, Shenzhen, Guangdong province, 581033, China.
[11]Department of Hepatology, Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, 710003, China.
[12]Department of Hepatology, The First Hospital Affiliated to Hunan University of Chinese Medicine, Changsha, 410007, China.
[13]School of Applied Science and Information Engineering, Beijing University of Science and Technology, Beijing, 100083, China.
语种：

英文
期刊：

Chinese journal of integrative medicine ISSN：1672-0415 2016 年 ; 2016-Dec-08
收录：
关键词：

Chinese medicine Shuanghu Qinggan Granule YiganYiqi Jieyu Granule chronic hepatitis B lamivudine randomized controlled trial
摘要：

To observe the clinical efficacy and safety of Shuanghu Qinggan Granule ( , SQG) plus Yigan Yiqi Jieyu Granule (, YYJG) combined with lamivudine (LAM) on chronic hepatitis B (CHB) patients.;The study was a multicenter, randomized, double-blinded and parallel controlled trial. A total of 320 patients were randomly allocated into 2 groups equally: 160 patients (treatment group) were given SQG and YYJG combined with LAM; and 160 patients (control group) were given LAM plus Chinese herb placebo, respectively. Liver functions, hepatitis B envelop antigen (HBeAg) titer levels, and hepatitis B virus DNA (HBV-DNA) load were monitored.;(1) In the 48th week, the treatment group showed superior HBeAg seroconversion rate than that in the control group (38.0% vs. 24.0%, P<0.05). (2) In the 48th week, the treatment group demonstrated lower HBeAg titer than that in the control group (P<0.05). (3) In the 12th, 24th, 48th week, there was no statistical significance in HBV-DNA response rate between the two groups. (4) In the 12th week, the level of glutamyl transpeptidase (GGT) was significantly decreased in the treatment group compared with the control group (P<0.05); in the 36th week, the levels of alanine aminotransferase and aspartate transaminase were significantly lower in the treatment group than those in the control group (P<0.05).;The protocol of SQG and YYJG combined with LAM to treat CHB showed superior efficacy than LAM monotherapy.;
推荐引用方式
GB/T 7714：

Ye Yong-An,Tian De-Lu,Jiang Jian, et al. Effect of Shuanghu Qinggan Granule () and Yigan Yiqi Jieyu Granule () plus lamivudine on chronic hepatitis B patients: A randomized double-blind placebo-controlled trial. [J].Chinese journal of integrative medicine,2016.
APA：

Ye Yong-An,Tian De-Lu,Jiang Jian,Li Jun,&Li Xiao-Ke.(2016).Effect of Shuanghu Qinggan Granule () and Yigan Yiqi Jieyu Granule () plus lamivudine on chronic hepatitis B patients: A randomized double-blind placebo-controlled trial. .Chinese journal of integrative medicine.
MLA：

Ye Yong-An, et al. "Effect of Shuanghu Qinggan Granule () and Yigan Yiqi Jieyu Granule () plus lamivudine on chronic hepatitis B patients: A randomized double-blind placebo-controlled trial." .Chinese journal of integrative medicine(2016).
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