An electrodialytic potassium hydroxide eluent generator (EDG) well-suited to small-bore (2 mm i.d.) ion chromatography (sIC) system is described. The basic configuration of EDG cartridge is much similar to that of conventional counterpart except lower void volume, which was measured to be (9) over tilde mu L relative to (3) over tilde1 mu L of conventional one. The corresponding dispersion volume was computed to be (5) over tilde8 mu L and (1) over tilde 06 mu L respectively. Lower void volume will improve the sharpness of a step gradient (or steeper rise curve), which is helpful to gradient elution. The device can bear the pressure up to at least 20.5 MPa and the effective KOH concentration that can be generated is ranging from 0.15 mM to 100 mM at the typical flow rate of sIC (0.4 mL/min). High purity of the produced KOH eluent and excellent running reproducibility of the device were observed, as indicated by the typical suppressed background (0.36 mu S/cm) and <0.11% (or <0.23%) of the relative standard deviation of the retention times for common inorganic anions achieved under isocratic (or gradient) mode. (C) 2019 Elsevier B.V. All rights reserved.
[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong RD, Shanghai 200237, Peoples R China.
[2]Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China.
(8.0+极速模式)