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Cognitive Improvement during Treatment for Mild Alzheimer's Disease with a Chinese Herbal Formula: A Randomized Controlled Trial 期刊论文

编号：

a1ae2f1e-b82a-48dc-99df-fa965669d644
作者：

Zhang, Yulian#*^[1]Lin, Cuiru#^[1]Zhang, Linlin^[2];Cui, Yuanwu^[1];Gu, Yun(顾耘)^[2]Guo, Jiakui^[1];Wu, Di^[3];Li, Qiang^[4];Song, Wanshan^[1];
语种：

英文
期刊：

PLOS ONE ISSN：1932-6203 2015 年 10 卷 6 期 ; JUN 15
收录：
摘要：

Objectives
To explore the efficacy of Chinese herbal formula compared with donepezil 5mg/day in patients with mild Alzheimer's disease (AD).
Methods
Patients with mild AD meeting the criteria were randomized into Chinese herbal formula Yishen Huazhuo decoction (YHD) group and donepezil hydrochloride (DH) group during the 24-week trial. The outcomes were measured by ADAS-cog, MMSE, ADL, and NPI with linear mixed-effect models.
Results
144 patients were randomized. The mean scores of ADAS-cog and MMSE in both YHD group and DH group both improved at the end of the 24-week treatment period. The results also revealed that YHD was better at improving the mean scores of ADAS-cog and MMSE than DH. Linear mixed-effect models with repeated measures showed statistical significance in time x group interaction effect of ADAS-cog and also in time x group interaction effect of MMSE. The data showed YHD was superior to DH in improving the scores and long term efficacy.
Conclusions
Our study suggests that Chinese herbal formula YHD is beneficial and effective for cognitive improvement in patients with mild AD and the mechanism might be through reducing amyloid-beta (A beta) plaque deposition in the hippocampus.
推荐引用方式
GB/T 7714：

Zhang Yulian,Lin Cuiru,Zhang Linlin, et al. Cognitive Improvement during Treatment for Mild Alzheimer's Disease with a Chinese Herbal Formula: A Randomized Controlled Trial [J].PLOS ONE,2015,10(6).
APA：

Zhang Yulian,Lin Cuiru,Zhang Linlin,Cui Yuanwu,&Song Wanshan.(2015).Cognitive Improvement during Treatment for Mild Alzheimer's Disease with a Chinese Herbal Formula: A Randomized Controlled Trial .PLOS ONE,10(6).
MLA：

Zhang Yulian, et al. "Cognitive Improvement during Treatment for Mild Alzheimer's Disease with a Chinese Herbal Formula: A Randomized Controlled Trial" .PLOS ONE 10,6(2015).
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