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The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45 alpha 期刊论文

编号：

9f1fbb89-9f48-43dd-a894-c97a5cb7e4f5
作者：

Zheng, Zhaoqing#^[1,2]Wu, Man(吴曼)#^[1,2]Zhang, Juan^[1,2];Fu, Wenwei(付文卫)^[1,2]Xu, Naihan^[3];Lao, Yuanzhi(劳远至)^[1,2]Lin, Lan*^[4]Xu, Hongxi(徐宏喜)*^[1,2]
语种：

英文
期刊：

FRONTIERS IN ONCOLOGY ISSN：2234-943X 2019 年 9 卷 ; JUL 17
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关键词：

neobractatin cell cycle E2F1 GADD45 alpha RNA-Seq GSEA
摘要：

The complexity and multi-target feature of natural compounds have made it difficult to elucidate their mechanism of action (MoA), which hindered the development of lead anticancer compounds to some extent. In this study, we applied RNA-Seq and GSEA transcriptome analysis to rapidly and efficiently evaluate the anticancer mechanisms of neobractatin (NBT), a caged prenylxanthone isolated from the Chinese herb Garcinia bracteata. We found that NBT exerted anti-proliferative effect on various cancer cells and caused both G1/S and G2/M arrest in synchronized cancer cells through its effects on the expression of E2F1 and GADD45 alpha. The in vivo animal study further suggested that NBT could reduce tumor burden in HeLa xenograft model with no apparent toxicity. By demonstrating the biological effect of NBT, we provided evidences for further investigations of this novel natural compound with anticancer potential.
推荐引用方式
GB/T 7714：

Zheng Zhaoqing,Wu Man,Zhang Juan, et al. The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45 alpha [J].FRONTIERS IN ONCOLOGY,2019,9.
APA：

Zheng Zhaoqing,Wu Man,Zhang Juan,Fu Wenwei,&Xu Hongxi.(2019).The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45 alpha .FRONTIERS IN ONCOLOGY,9.
MLA：

Zheng Zhaoqing, et al. "The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45 alpha" .FRONTIERS IN ONCOLOGY 9(2019).
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