The CuH-catalyzed asymmetric intramolecular reductive coupling of allenes to enones is successfully realized, providing cis-hydrobenzofurans with promising yields and excellent enantioselectivities. Such brilliant enantioselectivities are partially contributed by CuH-catalyzed favorable kinetic resolution of the cyclization products. This protocol tolerates a broad range of functional groups, allowing for further construction of tricyclic and bridged-ring structures. Moreover, the meta-chiral functionalization of 4-substituted phenol and asymmetric dearomatization modification of phenol-contained bioactive molecules are also described.
[1]Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Synthet Chem Nat Subst, 345 Lingling Rd, Shanghai 200032, Peoples R China.
[2]Shanghai Univ, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China.
[3]Shanghai Univ Tradit Chinese Med, Inst Innovat Chinese Med ICM, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
(8.0+极速模式)