Transforming growth factor (3-stimulated clone 22 domain 1 (TSC22) has been identified as a cancer suppressor gene in various kinds of cancers. The purpose of this study was to explore the expression of TSC22 in colorectal cancer (CRC) tissues and cell lines. 24 matched CRC and normal tissue samples by qPCR along with 18 pairs of them by Western blot demonstrated TSC22 level was decreased in CRC compared with normal tissue. The protein expression of TSC22 was examined in 310 CRC specimens. Results showed low expression of TSC22 was significantly correlated with tumor size (P = 0.048) and tumor infiltration (P = 0.016). Kaplan-Meier method suggested low expression of TSC22 was inversely associated with OS for 276 samples (P < 0.01). Multivariate Cox regression analysis confirmed TSC22 expression as independent predictors of the OS in CRC patients. Furthermore, we found TSC22 could suppress tumor by inhibiting cell proliferation in CRC cell lines. (C) 2018 Elsevier Inc. All rights reserved.
[1]Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Gastrointestinal Surg, 160 Pujian Rd, Shanghai 200127, Peoples R China.
[2]Jiading Hosp Tradit Chinese Med, Dept Gastrointestinal Surg, Shanghai 201800, Peoples R China.
[3]Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Oncol, Shanghai 200127, Peoples R China.
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