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19q genotyping in oligodendroglial tumours 期刊论文

编号：

8f829e58-090c-4fb6-bb7f-1e5c48575e95
作者：

Xiong, Ji#^[1,2]Tan, Wenli(谭文莉)#^[3]Wen, Jianbo^[1];Pan, Jiawei^[1];Wang, Yin^[2];Zhang, Jun*^[1]Geng, Daoying*^[1]
语种：

英文
期刊：

EUROPEAN RADIOLOGY ISSN：0938-7994 2016 年 26 卷 6 期 (1705 - 1715) ; JUN
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关键词：

Conventional MRI Diffusion tensor imaging 1p/19q codeletion Isocitrate dehydrogenase gene Oligodendroglial tumours
摘要：

To explore the correlations of conventional MRI (cMRI) and diffusion tensor imaging (DTI) values with the 1p/19 codeletion and IDH mutations in oligodendroglial tumours (OTs).
Eighty-four patients with OTs who underwent cMRI and DTI were retrospectively reviewed. The maximal fractional anisotropy and minimal apparent diffusion coefficient (ADC) were measured and compared using the Mann-Whitney U test. Receiver operating characteristic curves, logistic regression analysis and four-table statistics analysis were performed to predict genotypings.
OTs with 1p/19q codeletion or IDH mutations were prone to locate in frontal (P = 0.106 and 0.005, respectively) and insular lobes and were associated with absent or blurry contrast enhancement (P = 0.040 and 0.013, respectively). DTI values showed significant differences between OTs with and without IDH mutations (P < 0.05) but not in OTs with and without 1p/19q loss. The Ki-67 index significantly correlated with IDH mutations (P = 0.002) but not with 1p/19q codeletion. A combination of DTI and cMRI for the identification of IDH mutations resulted in sensitivity, specificity, positive and negative predictive values of 92.2 %, 75.8 %, 93.8 % and 71.1 %, respectively.
Combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in OTs.
aEuro cent OTs with 1p/19q codeletion were associated with absent or blurry contrast enhancement
aEuro cent OTs with IDH mutations were also associated with absent or blurry contrast enhancement
aEuro cent OTs with IDH mutations were prone to locate in frontal and insular lobes
aEuro cent DTI values can provide a non-invasive method for assessing the IDH status of OTs
aEuro cent A combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations.
推荐引用方式
GB/T 7714：

Xiong Ji,Tan Wenli,Wen Jianbo, et al. Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours [J].EUROPEAN RADIOLOGY,2016,26(6):1705-1715.
APA：

Xiong Ji,Tan Wenli,Wen Jianbo,Pan Jiawei,&Geng Daoying.(2016).Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours .EUROPEAN RADIOLOGY,26(6):1705-1715.
MLA：

Xiong Ji, et al. "Combination of diffusion tensor imaging and conventional MRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in oligodendroglial tumours" .EUROPEAN RADIOLOGY 26,6(2016):1705-1715.
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