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Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells 期刊论文

编号：

8b46d10f-6dd3-4bf6-a1b7-e19105f7be27
作者：

Que, Zujun(阙祖俊)#^[2]Zhou, Zhiyi(周之毅)#^[1]Luo, Bin(罗斌)^[1]Dong, Changsheng^[2];Jiang, Yi^[1];Li, Hegen(李和根)*^[1]Tian, Jianhui(田建辉)*^[1,2]
语种：

英文
期刊：

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE ISSN：1472-6882 2019 年 19 卷 1 期 ; AUG 7
收录：
关键词：

Non-small cell lung cancer Circulating tumor cell Jinfukang Apoptosis Oxidative stress
摘要：

Background Metastasis is the main cause of lung cancer death. As a seed of metastasis, circulating tumor cells are an important target for metastasis intervention. The traditional Chinese medicine, Jinfukang, has been clinically available for the treatment of non-small cell lung cancer (NSCLC). In this study, we investigated the action and underlying mechanisms of Jinfukang against circulating lung tumor cells. Methods The cell counting kit-8 (CCK-8), colony formation and cell cycle assays were used to study the cell proliferation ability. Flow cytometry was used to detect the apoptosis and the expression level of ROS and Caspase-3. Comet and TUNEL assays were used to detect DNA damage. DNA damage related pathway protein was detected by western blot. Results Jinfukang significantly inhibits the proliferation of CTC-TJH-01 cells by inducing G1 phase arrest and inhibits their colony formation in a dose-dependent manner. Moreover, Jinfukang induces apoptosis in CTC-TJH-01 cells through the ROS-mediated ATM/ATR-p53 pathway and DNA damage. Conclusions Our findings suggest that Jinfukang may be a potential drug for lung cancer metastasis.
推荐引用方式
GB/T 7714：

Que Zujun,Zhou Zhiyi,Luo Bin, et al. Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells [J].BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2019,19(1).
APA：

Que Zujun,Zhou Zhiyi,Luo Bin,Dong Changsheng,&Tian Jianhui.(2019).Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells .BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,19(1).
MLA：

Que Zujun, et al. "Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells" .BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 19,1(2019).
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