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Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice 期刊论文

编号：

830e48c6-fed9-45ea-8f56-92a59030ce4f
作者：

Teng, Haifeng#*^[1]Chen, Meng^[2];Zou, Ansheng^[3];Jiang, Haili(江海丽)^[4]Han, Jichun^[5];Sun, Long^[6];Feng, Chao^[7];Liu, Ju^[5];
语种：

英文
期刊：

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES ISSN：2008-3866 2016 年 19 卷 8 期 (910 - 915) ; AUG
收录：
关键词：

Antioxidant Anti-inflammatory Carbon tetrachloride Hepatotoxicity Licochalcone B NF-kappa B P38
摘要：

Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity.
Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and 25 mg/kg/day. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione disulfide (GSSG), C-reactive protein (CRP), tumor necrosis factor-a (TNF-alpha), interleukin-6 (IL-6), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed by ELISA. The protein expression degrees of p38 mitogen activated protein kinases (p38) and nuclear factor-k-gene binding (NF-kappa B) were assayed by western blotting.
Results: CCl4-induced hepatotoxicity was manifested by an increase in the levels of ALT, AST, MDA, IL-6, CRP, and TNF-alpha, and a decrease in the SOD level and GSH/GSSG ratio in the serum. The histopathological examination of the liver sections revealed necrosis and inflammatory reactions. Pretreatment with LCB decreased the levels of ALT, AST, MDA, GSSG, IL-6, CRP, TNF-alpha, and the protein expression of p38 and NF-kappa B, increased the level of SOD and GSH, and normalized the hepatic histoarchitecture.
Conclusion: LCB protected the liver from CCl4-induced injury. Protection may be due to inhibition of p38 and NF-kappa B signaling, which subsequently reduced inflammation in the liver.
推荐引用方式
GB/T 7714：

Teng Haifeng,Chen Meng,Zou Ansheng, et al. Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice [J].IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES,2016,19(8):910-915.
APA：

Teng Haifeng,Chen Meng,Zou Ansheng,Jiang Haili,&Liu Ju.(2016).Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice .IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES,19(8):910-915.
MLA：

Teng Haifeng, et al. "Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice" .IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES 19,8(2016):910-915.
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