首页 / 院系成果 / 成果详情页

THE CONTRAST EFFECT OF MAGNETIC RESONANCE TARGET CONTRAST AGENT RGD AND KMnF3 COUPLING NANOPARTICLE ON MICE MODELS OF BREAST CANCER 期刊论文

编号：

8078ae80-e35a-4825-b41d-e74c15ff561a
作者：

Wui, Xiaoyan#^[1]Zhan, Songhua(詹松华)*^[1]Li, Wei^[2,3];Yang, Xuerong^[1];Yang, Yuchan(杨玉婵)^[1]Cheng, Jianmin^[1];Lu, Mengying(陆孟莹)^[1]Zhang, Min^[1];Chen, Yan^[4];
语种：

英文
期刊：

ACTA MEDICA MEDITERRANEA ISSN：0393-6384 2019 年 35 卷 4 期 (1723 - 1728)
收录：
关键词：

KMnF3 magnetic resonance breast cancer nanoparticle
摘要：

Objective: The objective of the paper is to explore the contrast effect of magnetic resonance target contrast agent RGD and KMnF3 coupling nanoparticle on mice models of breast cancer.
Method: The manganese oleate was prepared to further synthesize the c(RGDyK) peptide coupling KMnF3 nanoparticle. The na-noparticle was subjected to the analysis of the cell relaxation efficiency and cytotoxicity. Based on the results of the former analysis, the prepared materials were applied to the magnetic resonance imaging (MRI) scan for performance analysis and contrast effect observation.
Results: The results have shown that in terms of the contour of the prepared materials, the variation of size and distribution of nanoparticle was little; after several weeks, obvious particle aggregation was hardly observed through visual inspection. In terms of the relaxation and cytotoxicity of the prepared materials, the experimental results have shown that the cell survival rate was relatively high, reaching above 90%; in terms of the application of prepared materials into the mice models of breast cancer, the interaction of c(RGDyK) coupling KMnF3 nanoparticle and polypeptide-integrin could be inferred from the immunohistochemical analysis.
Conclusion: Therefore, the study of the contrast effect of magnetic resonance target contrast agent RGD and KMnF3 cou-pling nanoparticle on mice models of breast cancer proposed in the paper would explore the diagnostic value of nanoparticle as a target contrast agent for tumors. Despite the deficiencies in the experimental process, it could provide the application of contrast agent in the subsequent clinical diagnosis of guidance.
推荐引用方式
GB/T 7714：

Wui Xiaoyan,Zhan Songhua,Li Wei, et al. THE CONTRAST EFFECT OF MAGNETIC RESONANCE TARGET CONTRAST AGENT RGD AND KMnF3 COUPLING NANOPARTICLE ON MICE MODELS OF BREAST CANCER [J].ACTA MEDICA MEDITERRANEA,2019,35(4):1723-1728.
APA：

Wui Xiaoyan,Zhan Songhua,Li Wei,Yang Xuerong,&Chen Yan.(2019).THE CONTRAST EFFECT OF MAGNETIC RESONANCE TARGET CONTRAST AGENT RGD AND KMnF3 COUPLING NANOPARTICLE ON MICE MODELS OF BREAST CANCER .ACTA MEDICA MEDITERRANEA,35(4):1723-1728.
MLA：

Wui Xiaoyan, et al. "THE CONTRAST EFFECT OF MAGNETIC RESONANCE TARGET CONTRAST AGENT RGD AND KMnF3 COUPLING NANOPARTICLE ON MICE MODELS OF BREAST CANCER" .ACTA MEDICA MEDITERRANEA 35,4(2019):1723-1728.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：162  下载次数：0

分享到：

浏览次数：162

下载次数：0

打印次数：0