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Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer 期刊论文

编号：

7572e75e-6016-4e5f-bca2-5102a6231123
作者：

Ding, Zhijie#^[1,2]Lao, Yuanzhi(劳远至)^[1,2]Zhang, Hong(张洪)^[1,2]Fu, Wenwei(付文卫)^[1,2]Zhu, Lunlun(祝伦伦)^[1,2]Tan, Hongsheng(谭红胜)^[1,2]Xu, Hongxi(徐宏喜)*^[1,2]
语种：

英文
期刊：

ONCOTARGET ISSN：1949-2553 2016 年 7 卷 2 期 (1826 - 1837) ; JAN 12
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关键词：

Griffipavixanthone RAF esophageal cancer metastasis natural product
摘要：

Metastasis causes a large number of deaths among esophageal cancer patients. The activation of RAF family proteins elevates tumor metastasis and proliferation. In screen targeting the RAF protein, we identified that Griffipavixanthone (GPX), a dimeric xanthone isolated from Garcinia esculenta, is a B-RAF and C-RAF inhibitor against esophageal cancer cells. Using wound healing, transwell migration and matrigel invasion assays, we confirmed that GPX significantly inhibited cell migration and invasion. Furthermore, exposure to GPX rendered cell proliferation and induced G2/M cell cycle arrest. Our mechanistic study showed that GPX suppressed cancer metastasis and proliferation through downregulation of RAF-MEK-ERK cascades proteins as well as RAF mRNA levels. In a pulmonary metastasis model, the intraperitoneal injection of GPX significantly suppressed esophageal tumor metastasis and ERK protein level in vivo. In conclusion, our present study suggested that GPX could inhibit tumor migration, invasion and proliferation in vitro and in vivo, which indicated the potential of GPX for preventing and treating esophageal cancer.
推荐引用方式
GB/T 7714：

Ding Zhijie,Lao Yuanzhi,Zhang Hong, et al. Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer [J].ONCOTARGET,2016,7(2):1826-1837.
APA：

Ding Zhijie,Lao Yuanzhi,Zhang Hong,Fu Wenwei,&Xu Hongxi.(2016).Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer .ONCOTARGET,7(2):1826-1837.
MLA：

Ding Zhijie, et al. "Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer" .ONCOTARGET 7,2(2016):1826-1837.
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