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Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes 期刊论文

编号：

7381bb96-195e-4ac0-af9d-d2e938f3fd32
作者：

Zhang, Xiao(张笑)#^[1,2]Du, Guangli(都广礼)^[1,2]Xu, Ying^[1,2];Li, Xuewei^[1,2];Fan, Weiwei^[1,2];Chen, Jiamei^[1,2];Liu, Cheng^[1,2];Chen, Gaofeng^[1,2];Liu, Chenghai(刘成海)^[1,2]Zern, Mark A.^[3];Mu, Yongping(慕永平)*^[1,2]Liu, Ping(刘平)*^[1,2]
语种：

英文
期刊：

LABORATORY INVESTIGATION ISSN：0023-6837 2016 年 96 卷 3 期 (350 - 360) ; MAR
收录：
摘要：

Although hepatic progenitor cells (HPCs) are known to contribute to cholestatic liver fibrosis (CLF), how Notch signaling modulates the differentiation of HPCs to cholangiocytes in CLF is unknown. Thus, using a rat model of CLF that is induced by bile duct ligation, we inhibited Notch signaling with DAPT. In vivo, CK19, OV6, Sox9, and EpCAM expression was increased significantly. Notch signaling increased after bile duct ligation, and DAPT treatment reduced the expression of CK19, OV6, Sox9, and EpCAM and blocked cholangiocyte proliferation and CLF. In vitro, treatment of a WB-F344 cell line with sodium butyrate resulted in increased mRNA and protein expression of CK19, Sox9, and EpCAM, but Notch signaling was activated. Both of these processes were inhibited by DAPT. This study reveals that Notch signaling activation is required for HPC differentiation into cholangiocytes in CLF, and inhibition of the Notch signaling pathway may offer a therapeutic approach for treating CLF.
推荐引用方式
GB/T 7714：

Zhang Xiao,Du Guangli,Xu Ying, et al. Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes [J].LABORATORY INVESTIGATION,2016,96(3):350-360.
APA：

Zhang Xiao,Du Guangli,Xu Ying,Li Xuewei,&Liu Ping.(2016).Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes .LABORATORY INVESTIGATION,96(3):350-360.
MLA：

Zhang Xiao, et al. "Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes" .LABORATORY INVESTIGATION 96,3(2016):350-360.
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