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Regulation of microbiota-GLP1 axis by sennoside A in diet-induced obese mice 期刊论文

编号：

736dcecf-296d-4187-8459-e8cf70126713
作者：

Le, Jiamei#^[1,2]Zhang, Xiaoying(章晓鹰)^[3]Jia, Weiping^[4];Zhang, Yong^[5];Luo, Juntao^[3];Sun, Yongning*^[2,6]Ye, Jianping*^[3,4,5]
语种：

英文
期刊：

ACTA PHARMACEUTICA SINICA B ISSN：2211-3835 2019 年 9 卷 4 期 (758 - 768) ; JUL
收录：
关键词：

Sennoside A Insulin sensitivity Mitochondria Gut microbiota Short chain fatty acids GLP1
摘要：

Sennoside A (SA) is a bioactive component of Chinese herbal medicines with an activity of irritant laxative, which is often used in the treatment of constipation and obesity. However, its activity remains unknown in the regulation of insulin sensitivity. In this study, the impact of SA on insulin sensitivity was tested in high fat diet (HFD)-induced obese mice through dietary supplementation. At a dosage of 30 mg/kg/day, SA improved insulin sensitivity in the mice after 8-week treatment as indicated by HOMA-IR (homeostatic model assessment for insulin resistance) and glucose tolerance test (GTT). SA restored plasma level of glucagon-like peptide 1 (GLP1) by 90% and mRNA expression of Glpl by 80% in the large intestine of HFD mice. In the mechanism, SA restored the gut microbiota profile, short chain fatty acids (SCFAs), and mucosal structure in the colon. A mitochondrial stress was observed in the enterocytes of HFD mice with ATP elevation, structural damage, and complex dysfunction. The mitochondrial response was induced in enterocytes by the dietary fat as the same responses were induced by palmitic acid in the cell culture. The mitochondrial response was inhibited in HFD mice by SA treatment. These data suggest that SA may restore the function of microbiota GLP1 axis to improve glucose metabolism in the obese mice. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
推荐引用方式
GB/T 7714：

Le Jiamei,Zhang Xiaoying,Jia Weiping, et al. Regulation of microbiota-GLP1 axis by sennoside A in diet-induced obese mice [J].ACTA PHARMACEUTICA SINICA B,2019,9(4):758-768.
APA：

Le Jiamei,Zhang Xiaoying,Jia Weiping,Zhang Yong,&Ye Jianping.(2019).Regulation of microbiota-GLP1 axis by sennoside A in diet-induced obese mice .ACTA PHARMACEUTICA SINICA B,9(4):758-768.
MLA：

Le Jiamei, et al. "Regulation of microbiota-GLP1 axis by sennoside A in diet-induced obese mice" .ACTA PHARMACEUTICA SINICA B 9,4(2019):758-768.
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