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Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism 期刊论文

编号：

71348ff3-d4a7-4117-91e0-52050647c400
作者：

Ren, RuJing^[1,2];Zhang, YongFang^[3];Dammer, Eric B.^[4,5];Zhou, Yi^[1,2];Wang, Liling^[1,2];Liu, XiaoHong^[6];Feng, BeiLei(冯蓓蕾)^[7]Jiang, GuoXin^[8];Chen, ShengDi^[1,2,9,10];Wang, Gang^[1,2];Cheng, Qi^[1,2,11];
语种：

英文
期刊：

MOLECULAR NEUROBIOLOGY ISSN：0893-7648 2016 年 53 卷 8 期 (5772 - 5781) ; OCT
收录：
关键词：

Alzheimer's disease MicroRNA Expression profiles beta-site APP cleaving enzyme
摘要：

A series of investigations have been performed regarding microRNA (miRNA, miR) of Alzheimer's disease (AD) patients. However, most of these used microarray with neither validation by PCR nor any follow-up on the biological mechanism implicated by findings. Further, there were rarely any analyses linking clinical phenotype of de novo, drug-naive patients to cellular pathogenic mechanism(s) to date. Microarray screening followed by validation via quantitative PCR (Q-PCR) assays and the relationship between miRNAs and phenotypic indices were evaluated. Additionally, the cellular mechanism of miRNAs through effects of beta-site amyloid precursor protein (APP) cleaving enzyme (BACE1) was assessed. We identified 2 specific differentially expressed (DE) miRNAs (miR-339 and miR-425) as potential diagnostic biomarkers for AD and revealed that these DE miRNAs could be involved in modulating the pathogenesis of AD via BACE1 protein inhibition. The findings presented here reveal a detailed snapshot of the profile of peripheral blood mononuclear cells (PBMC) miRNA changes in AD patients, association with clinical phenotype, and potential roles in cellular pathogenesis.
推荐引用方式
GB/T 7714：

Ren Ru-Jing,Zhang Yong-Fang,Dammer Eric B., et al. Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism [J].MOLECULAR NEUROBIOLOGY,2016,53(8):5772-5781.
APA：

Ren Ru-Jing,Zhang Yong-Fang,Dammer Eric B.,Zhou Yi,&Cheng Qi.(2016).Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism .MOLECULAR NEUROBIOLOGY,53(8):5772-5781.
MLA：

Ren Ru-Jing, et al. "Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism" .MOLECULAR NEUROBIOLOGY 53,8(2016):5772-5781.
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