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The PD-1/PD-Ls pathway is up-regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides 期刊论文

编号：

6f4a5230-8447-4856-aae0-a4a156edb289
作者：

Sun, Yu(孙宇)#^[1]Jing, Yuanya^[2];Huang, Mengwen^[2];Ma, Jinyun^[1];Peng, Xiaoyan^[1];Wang, Jinying^[1];Li, Guoling^[1];Cheng, Xiaodong(程晓东)*^[1,2]
语种：

英文
期刊：

JOURNAL OF NEUROIMMUNOLOGY ISSN：0165-5728 2019 年 332 卷 (78 - 90) ; JUL 15
收录：
关键词：

PD-1/PD-Ls molecules EAE CNS T lymphocytes Astragalus polysaccharides
摘要：

Multiple sclerosis (MS) is an inflammatory demyelinating disease of CNS. Astragalus polysaccharides (APS), the main active extract from astragalus membranaceus which is a kind of traditional Chinese medicinal herb, is associated with a variety of immunomodulatory activities. We have evaluated the therapeutic effects of APS in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). It was found that APS could effectively alleviate EAE through inhibiting MOG(35-55)-specific T cell proliferation and reducing the expression of proinflammatory cytokines, which is mediated by up-regulating the expression of PD-1/PD-Ls signaling pathway. Our results demonstrated that EAE could be suppressed significantly by APS administration. It indicated that APS might be a potential of developing innovative drug for the therapy of MS.
推荐引用方式
GB/T 7714：

Sun Yu,Jing Yuanya,Huang Mengwen, et al. The PD-1/PD-Ls pathway is up-regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides [J].JOURNAL OF NEUROIMMUNOLOGY,2019,332:78-90.
APA：

Sun Yu,Jing Yuanya,Huang Mengwen,Ma Jinyun,&Cheng Xiaodong.(2019).The PD-1/PD-Ls pathway is up-regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides .JOURNAL OF NEUROIMMUNOLOGY,332:78-90.
MLA：

Sun Yu, et al. "The PD-1/PD-Ls pathway is up-regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides" .JOURNAL OF NEUROIMMUNOLOGY 332(2019):78-90.
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