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Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-beta signaling 期刊论文

编号：

6c0470db-e37a-4cc4-80a0-6cec93c166e7
作者：

Guo, Lu#^[1]Gao, Ziyang(高子阳)#^[1]Zhang, Liuqiang(张刘强)^[1]Guo, Fujiang(郭夫江)^[1]Chen, Yan^[2];Li, Yiming(李医明)*^[1]Huang, Cheng(黄诚)*^[1]
语种：

英文
期刊：

PHARMACEUTICAL BIOLOGY ISSN：1388-0209 2016 年 54 卷 8 期 (1312 - 1325) ; AUG
收录：
关键词：

ABCA1 nRNAs antihyperlipidemia C57/BL6 mice Echinoside A Pearsonothuria graeffei
摘要：

Context: Sea cucumbers have been consumed as tonic, food, and nutrition supplements for many years.
Objective: The objective of this study is to investigate the antiobesity and lipid-lowering effects of sea cucumber extracts in in vitro and in vivo models and elucidate the mechanism of action of the extracts on obesity and dyslipidemia.
Materials and methods: The 60% ethanol extracts from the body walls of 10 different sea cucumbers were investigated for the inhibition of pancreatic lipase (PL) activity in vitro. The optimal active extract (SC-3) was further chemically analyzed by LC-MS and UV. And 0.1% and 0.2% of SC-3 was mixed with a high-fat diet to treat C57/BL6 mice for 6 weeks or 2 weeks as preventive and therapeutic study. The body weight, serum, and liver lipid profile in the mice were investigated.
Results: The crude extract of Pearsonothuria graeffei Semper (Holothuriidae) inhibited the PL activity by 36.44% of control at 0.5 mu g/mL. SC-3 and echinoside A inhibited PL with an IC50 value at 2.86 mu g/mL and 0.76 mu M. 0.1% of SC-3 reduced the body weight (23.0 +/- 0.62 versus 26.3 +/- 0.76 g), the serum TC (2.46 +/- 0.04 versus 2.83 +/- 0.12mmol/L), TG (0.19 +/- 0.08 versus 0.40 +/- 0.03mmo/L), and LDL-c (0.48 +/- 0.02 versus 0.51 +/- 0.02mmol/L), and liver TC (1.19 +/- 0.17 versus 1.85 +/- 0.13mmol/mg) and TG (6.18 +/- 0.92 versus 10.87 +/- 0.97mmol/mg) contents of the obese C57BL/six mice on a high-fat diet.
Discussion and conclusion: Sea cucumber may be used for developing antiobesity and antihyperlipidemia drugs.
推荐引用方式
GB/T 7714：

Guo Lu,Gao Ziyang,Zhang Liuqiang, et al. Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-beta signaling [J].PHARMACEUTICAL BIOLOGY,2016,54(8):1312-1325.
APA：

Guo Lu,Gao Ziyang,Zhang Liuqiang,Guo Fujiang,&Huang Cheng.(2016).Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-beta signaling .PHARMACEUTICAL BIOLOGY,54(8):1312-1325.
MLA：

Guo Lu, et al. "Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-beta signaling" .PHARMACEUTICAL BIOLOGY 54,8(2016):1312-1325.
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