Acupuncture and moxibustion have been shown to be effective in treating Crohn's disease (CD), but their therapeutic mechanisms remain unclear. Here we compared brain responses to either electro-acupuncture or moxibustion treatment in CD patients experiencing remission. A total of 65 patients were randomly divided into an electro-acupuncture group (n = 32) or a moxibustion group (n = 33), and treated for 12 weeks. Eighteen patients in the electro-acupuncture group and 20 patients in the moxibustion group underwent resting-state functional magnetic resonance imaging at baseline and after treatment. Seed-based analysis was used to compare the restingstate functional connectivity (rsFC) between bilateral hippocampus and other brain regions before and after the treatments, as well as between the two groups. The CD activity index (CDAI) and inflammatory bowel disease questionnaire (IBDQ) were used to evaluate disease severity and patient quality of life. Electro-acupuncture and moxibustion both significantly reduced CDAI values and increased IBDQ scores. In the electro-acupuncture group, the rsFC values between bilateral hippocampus and anterior middle cingulate cortex (MCC) and insula were significantly increased, and the changes were negatively correlated with the CDAI scores. In the moxibustion group, the rsFC values between bilateral hippocampus and precuneus as well as inferior parietal lobe (IPC) were significantly elevated, and the changes were negatively correlated with the CDAI scores. We conclude that the therapeutic effects of electro-acupuncture and moxibustion on CD may involve the differently modulating brain homeostatic afferent processing network and default mode network (DMN), respectively.
[1]Shanghai Univ Tradit Chinese Med, Key Lab Acupuncture & Immunol Effects, Shanghai, Peoples R China.
[2]Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian, Shaanxi, Peoples R China.
[3]Shanghai Univ Tradit Chinese Med, Shanghai Res Inst Acupuncture & Meridian, Outpatient Dept, Shanghai, Peoples R China.
[4]Indiana Univ Sch Med, Stark Neurosci Res Inst, Indianapolis, IN 46202 USA.
[5]Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai, Peoples R China.
[6]Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Dept Radiol, Shanghai, Peoples R China.
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