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Metabolic mechanisms of Fuzheng-Huayu formula against liver fibrosis in rats 期刊论文

编号：

68006131-6875-4dfb-86ba-7d8f5ebb7738
作者：

Hu, XueQing(呼雪庆)#^[1,2]Song, YaNan(宋雅楠)#^[1,3]Wu, Rong^[1];Cai, FeiFei(蔡菲菲)^[1]Zhang, Yongyu(张永煜)^[4]Peng, JingHua(彭景华)^[5]Hu, YiYang(胡义扬)*^[5]Su, ShiBing(苏式兵)*^[1]
语种：

英文
期刊：

JOURNAL OF ETHNOPHARMACOLOGY ISSN：0378-8741 2019 年 238 卷 ; JUN 28
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关键词：

Fuzheng-Huayu formula Gypenoside Cordyceps sinensis mycelia Amygdalin Metabolite Liver fibrosis
摘要：

Ethnopharmacological relevance: Fuzheng-Huayu formula (FZHY) is traditionally used to treat liver fibrosis in clinic. The study was conducted to investigate the metabolic mechanisms of FZHY against liver fibrosis in rats.
Materials and methods: Rats with CCl4-induced liver fibrosis were treated with FZHY and its components, including amygdalin, cordyceps polysaccharide and gypenoside, respecitively. Liver fibrosis and function were assesed by histopathological examination, Western blot and serum biochemical detection. Metabolic profiling of liver tissue, serum and urine in each group were detected by gas chromatography-mass spectrometry (GC-MS) and transcriptomic changes were tested by gene chip. RT-VCR was used to validate levels of different expressed genes (DEGs) with statistical significance. Metabolic network together with DEGs was constructed based on KEGG database.
Results: FZHY effectively improved liver fibrosis better than the mixture or single use of gypenoside, cordyceps sinensis mycelia and amygdalin. FZHY treatment widely modulated the metabolic profiles perturbed by liver fibrosis, involving several important metabolic pathways, including glycolysis/gluconeogenesis, glucose-alanine cycle, citrate cycle, galactose metabolism, tryptophan metabolism, urea cycle, etc. It also increased alanine and decreased glucose levels in liver tissue and decreased both of them in serum and urine, which were dysregulated by CCl4 treatment. Additionally, FZHY also upregulated expression of metabolic enzymes including Hk2, Adh1 and Gpt increased, and downregulated Gs and Acss2.
Conclusion: FZHY improved liver fibrosis in rats via altering the metabolic pathways and regulating gene expression of involved metabolic enzymes.
推荐引用方式
GB/T 7714：

Hu Xue-Qing,Song Ya-Nan,Wu Rong, et al. Metabolic mechanisms of Fuzheng-Huayu formula against liver fibrosis in rats [J].JOURNAL OF ETHNOPHARMACOLOGY,2019,238.
APA：

Hu Xue-Qing,Song Ya-Nan,Wu Rong,Cai Fei-Fei,&Su Shi-Bing.(2019).Metabolic mechanisms of Fuzheng-Huayu formula against liver fibrosis in rats .JOURNAL OF ETHNOPHARMACOLOGY,238.
MLA：

Hu Xue-Qing, et al. "Metabolic mechanisms of Fuzheng-Huayu formula against liver fibrosis in rats" .JOURNAL OF ETHNOPHARMACOLOGY 238(2019).
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