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Evaluation of intratumoral heterogeneity by using diffusion kurtosis imaging and stretched exponential diffusion-weighted imaging in an orthotopic hepatocellular carcinoma xenograft model 期刊论文

编号：

67c27949-065c-4dd1-8771-f8e3649b8af6
作者：

Guo, Ran#^[1,2]Yang, ShuoHui(杨硕慧)*^[3]Lu, Fang(陆方)^[3]Han, ZhiHong(韩志宏)^[4]Yan, Xu^[5];Fu, CaiXia^[6];Zhao, MengLong^[1,2];Lin, Jiang*^[1,2]
语种：

英文
期刊：

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY ISSN：2223-4292 2019 年 9 卷 9 期 (1566 - 1578) ; SEP
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关键词：

Tumor heterogeneity magnetic resonance imaging diffusion kurtosis imaging (DKI) stretched exponential model (SEM) hepatocellular carcinoma (HCC)
摘要：

Background: To investigate the value of diffusion kurtosis imaging (DKI) and diffusion-weighted imaging (DWI) with a stretched exponential model (SEM) in the evaluation of tumor heterogeneity in an orthotopic hepatocellular carcinoma (HCC) xenograft model.
Methods: Thirty orthotopic HCC xenograft nude mice models were established and randomly divided into two groups, the sorafenib induction group (n=15) and control group (n=15). Every mouse in each group underwent MRI with DKI and SEM on a 1.5T MR scanner at 7, 14, and 21 days after sorafenib intervention. DKI and SEM parameters including mean kurtosis (MK), mean diffusivity (MD), alpha, and distributed diffusion coefficient (DDC) were measured, calculated, and compared between the two groups and among different time points. Sequential correlations between histopathological results including necrotic fraction (NF), micro-vessel density (MVD), Ki-67 index, standard deviation (SD), and kurtosis from hematoxylin-eosin staining, and DKI and SEM parameters were analyzed.
Results: MK, MD, and DDC of HCC in the sorafenib induction group were significantly higher than those in the control group at each time point (P<0.05), while alpha was significantly lower (P<0.05). Significantly positive correlations were found between MK and NF (r=0.693, P=0.010), SD (r =0.785, P=0.003), kurtosis (r=0.779, P=0.003), between MD and NF (r=0.794, P=0.003), SD (r=0.629, P=0.020), kurtosis (r=0.645, P=0.018), and between DDC and NF (r=0.800, P=0.003), SD (r=0.636, P=0.020), kurtosis (r=0.664, P=0.016), and significantly negative correlations were observed between a and NF (r=-0.704, P=0.009), SD (r=-0.754, P=0.003), and kurtosis (r=-0.792, P=0.003) in the sorafenib induction group.
Conclusions: DKI and SEM parameters may be potentially useful for evaluating intratumoral heterogeneity in HCC.
推荐引用方式
GB/T 7714：

Guo Ran,Yang Shuo-Hui,Lu Fang, et al. Evaluation of intratumoral heterogeneity by using diffusion kurtosis imaging and stretched exponential diffusion-weighted imaging in an orthotopic hepatocellular carcinoma xenograft model [J].QUANTITATIVE IMAGING IN MEDICINE AND SURGERY,2019,9(9):1566-1578.
APA：

Guo Ran,Yang Shuo-Hui,Lu Fang,Han Zhi-Hong,&Lin Jiang.(2019).Evaluation of intratumoral heterogeneity by using diffusion kurtosis imaging and stretched exponential diffusion-weighted imaging in an orthotopic hepatocellular carcinoma xenograft model .QUANTITATIVE IMAGING IN MEDICINE AND SURGERY,9(9):1566-1578.
MLA：

Guo Ran, et al. "Evaluation of intratumoral heterogeneity by using diffusion kurtosis imaging and stretched exponential diffusion-weighted imaging in an orthotopic hepatocellular carcinoma xenograft model" .QUANTITATIVE IMAGING IN MEDICINE AND SURGERY 9,9(2019):1566-1578.
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