首页 / 院系成果 / 成果详情页

Effect of amygdalin on proliferation of rat hepatic fat-storing cells and collagen production in vitro. 期刊论文

编号：

6645679b-2cca-4aec-9a52-8e1ac2b1d25c
作者：

Xu L M(徐列明)#^[1]Liu C(刘成)^[1]Liu P(刘平)^[1]
地址：

[1]Lie-Ming Xu, Cheng Liu, Ping Liu, Liver Diseases Research Center, Shanghai Academy of Traditional Chinese Medicine, Shanghai 200032, China.
语种：

英文
期刊：

World journal of gastroenterology ISSN：1007-9327 1997 年 3 卷 2 期 (103 - ) ; 1997-Jun-15
收录：
关键词：

Amygdalin Biosynthesis Cirrhosis Collagen Drug effects Drug therapy Liver Pharmacology
摘要：

To study the anti-fibrotic mechanism of amygdalin, a component of Semen Persicae, on fat-storing cells (FSC).;Livers of normal adult rats were perfused with Pronas E and collagenase in situ. FSC were isolated by centrifugation with 11% Metrizamide. The subcultured FSC were incubated with 10(-4)-10(-8) mol/L amygdalin for 72 h, and then FSC proliferation and collagen production were assayed, respectively.;Low doses of amygdalin reduced incorporation of L-[(3)H]-thymidine into FSC and L-[5-(3)H]-proline into secreted collagenase-sensitive proteins and cell layer-associated collagenase-sensitive proteins. the strongest effects were seen for the 10(-8) mol/L dose of amygdalin, which inhibited the proliferation of FSC by 25.0%, and decreased collagen production in medium and cell layer by 24.2% and 26.8%, respectively.;An anti-fibrotic mechanism of amygdalin is to inhibit the proliferation and collagen production of active FSC.;
推荐引用方式
GB/T 7714：

Xu L M,Liu C,Liu P, et al. Effect of amygdalin on proliferation of rat hepatic fat-storing cells and collagen production in vitro. [J].World journal of gastroenterology,1997,3(2):103-.
APA：

Xu L M,Liu C,Liu P.(1997).Effect of amygdalin on proliferation of rat hepatic fat-storing cells and collagen production in vitro. .World journal of gastroenterology,3(2):103-.
MLA：

Xu L M, et al. "Effect of amygdalin on proliferation of rat hepatic fat-storing cells and collagen production in vitro." .World journal of gastroenterology 3,2(1997):103-.

浏览次数：68  下载次数：0

分享到：

浏览次数：68

下载次数：0

打印次数：0