Andrographolide (AND) and neoandrographolide (NEO) are the diterpenoids from the Andrographis paniculata (Acanthaceae). It is reported the diterpenoids exhibit a wide spectrum of biological activities. The aim of this study was to investigate the hypolipidemic effect of AND and NEO in hyperlipidemic mice induced by 75% yolk emulsion and in hyperlipidemic rats induced by high fat emulsion, respectively. The results showed that the levels of triglyceride, total cholesterol (TC) and low-density lipoprotein cholesterol were reduced by AND and NEO in a dose-dependent tendency in mice. Compared with the model group, the plasma TC levels of experimental groups with AND and NEO at 100mg/kg dosage decreased by 23.9 and 20.2% in rats, respectively (P<0.05). It was also found that the plasma aspartate transaminase and alanine transaminase levels were significantly decreased by feeding with AND and NEO in rats, compared with positive group (simvastatin) (P<0.01). Otherwise, AND and NEO could protect the cardiovascular due to down-regulation of iNOS expression and up-regulation of eNOS expression. In conclusion, AND and NEO have potent hypolipidemic effects and protect the cardiovascular without significant liver damage. Copyright (c) 2012 John Wiley & Sons, Ltd.
[1]Shanghai Univ Tradit Chinese Med, Inst Tradit Chinese Med, MOE Key Lab Standardizat Chinese Med, Shanghai 201210, Peoples R China.
[2]Shanghai Univ Tradit Chinese Med, Inst Tradit Chinese Med, SATCM Key Lab New Resources & Qual Evaluat Chines, Shanghai 201210, Peoples R China.
[3]Shanghai R&D Ctr Standardizat Chinese Med, Shanghai 201210, Peoples R China.
[4]Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Shanghai 201210, Peoples R China.
[5]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 3, Tradit Chinese Med Dept, Shanghai, Peoples R China.
(8.0+极速模式)