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Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis 期刊论文

编号：

5bf1eb0b-ad65-4313-8a4c-cd2f82573869
作者：

Liu, Li(刘丽)#^[2]Cui, Jingang(崔金刚)#^[1,2]Yang, Qinbo^[1,2];Jia, Chenglin^[2];Xiong, Minqi^[2];Ning, Bingbing^[2];Du, Xiaoye^[1,2];Wang, Peiwei^[1,2];Yu, Xintong^[1,2];Li, Li^[1,2];Wang, Wenjian^[1,2];Chen, Yu(陈瑜)*^[1,2]Zhang, Teng(张腾)^[1,2]
语种：

英文
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2014 年 449 卷 1 期 (55 - 61) ; JUN 20
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关键词：

Myocardial injury Fibrosis Reactive oxygen species Apocynin Gene expression
摘要：

Oxidative stress is mechanistically implicated in the pathogenesis of myocardial injury and the subsequent fibrogenic tissue remodeling. Therapies targeting oxidative stress in the process of myocardial fibrogenesis are still lacking and thus remain as an active research area in myocardial injury management. The current study evaluated the effects of a NADPH oxidase inhibitor, apocynin, on the production of reactive oxygen species and the development of myocardial fibrogenesis in isoproterenol (ISO)-induced myocardial injury mouse model. The results revealed a remarkable effect of apocynin on attenuating the development of myocardial necrotic lesions, inflammation and fibrogenesis. Additionally, the protective effects of apocynin against myocardial injuries were associated with suppressed expression of an array of genes implicated in inflammatory and fibrogenic responses. Our study thus provided for the first time the histopathological and molecular evidence supporting the therapeutic value of apocynin against the development of myocardial injuries, in particular, myocardial fibrogenesis, which will benefit the mechanism-based drug development targeting oxidative stress in preventing and/or treating related myocardial disorders. (C) 2014 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Liu Li,Cui Jingang,Yang Qinbo, et al. Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,449(1):55-61.
APA：

Liu Li,Cui Jingang,Yang Qinbo,Jia Chenglin,&Zhang Teng.(2014).Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,449(1):55-61.
MLA：

Liu Li, et al. "Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 449,1(2014):55-61.
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