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Healthy diet is associated with gene expression in blood: the Framingham Heart Study 期刊论文

编号：

568e1fbe-6ca0-4bcc-9e60-703a4a8cb212
作者：

Lin, Honghuang#*^[1,2,3]Rogers, Gail T.^[5,6];Lunetta, Kathryn L.^[1,2,7];Levy, Daniel^[1,2,8];Miao, Xiao^[9]Troy, Lisa M.^[10];Jacques, Paul F.^[5,6];Murabito, Joanne M.^[1,2,4];
语种：

英文
期刊：

AMERICAN JOURNAL OF CLINICAL NUTRITION ISSN：0002-9165 2019 年 110 卷 3 期 (742 - 749) ; SEP
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摘要：

Background: Genes in metabolic and nutrient signaling pathways play important roles in lifespan in model organisms and human longevity.
Objective: The aim of this study was to examine the relation of a quantitative measure of healthy diet to gene expression in a community-based cohort.
Methods: We used the 2015 Dietary Guidelines for Americans Adherence Index (DGAI) score to quantify key dietary recommendations of an overall healthy diet. Our current analyses included 2220 Offspring participants (mean age 66 +/- 9 y, 55.4% women) and 2941 Third-Generation participants (mean age 46 +/- 9 y, 54.5% women) from the Framingham Heart Study. Gene expression was profiled in blood through the use of the Affymetrix Human Exon 1.0 ST Array. We conducted a transcriptome-wide association study of DGAI adjusting for age, sex, smoking, cell counts, and technical covariates. We also constructed a combined gene score from genes significantly associated with DGAI.
Results: The DGAI was significantly associated with the expression of 19 genes (false discovery rate <0.05). The most significant gene, ARRDC3, is a member of the arrestin family of proteins, and evidence in animal models and human data suggests that this gene is a regulator of obesity and energy expenditure. The DGAI gene score was associated with body mass index (P = 1.4 x 10(-50)), fasting glucose concentration (P = 2.5 x 10(-11)), type 2 diabetes (P = 1.1 x 10(-5)), and metabolic syndrome (P = 1.8 x 10(-32)).
Conclusions: Healthier diet was associated with genes involved in metabolic function. Further work is needed to replicate our findings and investigate the relation of a healthy diet to altered gene regulation.
推荐引用方式
GB/T 7714：

Lin Honghuang,Rogers Gail T.,Lunetta Kathryn L., et al. Healthy diet is associated with gene expression in blood: the Framingham Heart Study [J].AMERICAN JOURNAL OF CLINICAL NUTRITION,2019,110(3):742-749.
APA：

Lin Honghuang,Rogers Gail T.,Lunetta Kathryn L.,Levy Daniel,&Murabito Joanne M..(2019).Healthy diet is associated with gene expression in blood: the Framingham Heart Study .AMERICAN JOURNAL OF CLINICAL NUTRITION,110(3):742-749.
MLA：

Lin Honghuang, et al. "Healthy diet is associated with gene expression in blood: the Framingham Heart Study" .AMERICAN JOURNAL OF CLINICAL NUTRITION 110,3(2019):742-749.
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