Drug delivery system studies aim to improve nanoparticle (NP) formulation to enable efficient delivery of NPs to tumors. However, NPs must be transported by blood or through direct injection. How NPs leave the circulatory system and how NPs diffuse into a tumor remain unclear, and this uncertainty is a limitation of drug delivery systems. The intimate connection between these questions and metabolism may be related to their biosafety in vivo. Thus, in this study, classical carrier SiO2 NPs were used as typical transport NPs, and fluorescein isothiocyanate (FITC) was used as the representative drug and tracer. As exosome and tunneling nanotubes (TNTs) are the most relevant mechanism for NP transportation and considering the local situation in a tumor, we focused on identifying this phenomenon and investigating TNTs. In conclusion, we effectively demonstrated that NPs can be transferred from cell to cell. Nanotubes may play an important role in this process.
[1]Shanghai Jiao Tong Univ, Nanjing Med Univ, Shanghai Gen Hosp, Trauma Ctr,Sch Med, Shanghai 201620, Peoples R China.
[2]Tongji Univ, Sch Med, Shanghai Pulm Hosp, Ultrasound Dept, Shanghai 200433, Peoples R China.
[3]Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Orthopaed Implants, Dept Orthopaed Surg,Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China.
[4]Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Inst Translat Med, Shanghai 201620, Peoples R China.
[5]Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Radiol, Shanghai 201203, Peoples R China.
[6]Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China.
[7]Shanghai Gen Hosp, Baoshan Branch, Dept Orthopaed, Shanghai 200940, Peoples R China.
(8.0+极速模式)