The patient with prurigo nodularis were treated by needling at Baihui (GV 20), Fengchi (GB 20), Fengfu (GV 16), Dazhui (GV 14), Fengmen (BL 12), Xinshu (BL 15), Ganshu (BL 18), Qihai (CV 6), Guanyuan (CV 4), Zhongwan (CV12), Xuehai (SP 10), Zusanli (ST 36), Sanyinjiao (SP 6), Neiting (ST 44), Quchi (LI 11), Waiguan (TE 5) and Hegu (LI 4). The treatment was given 4 times a week. After 2 weeks of treatment, the subjective pruritus was alleviated and tolerable. The patients could fall into sleep. After 2 months of treatment, no new skin rashes appear and pruritus disappeared basically, the old rashes started fading. The red color was getting pale and the bumpy rashes were absorbed. After 5 months of treatment, the itching symptoms were gone and skin rashes disappeared basically. The lesion skin was pigmented in dark grey. After 6 months of treatment, the dark grey pigmentation disappeared and skin was normal in color. The disease was not recurred in 1 year of follow-up. (C) 2018 Published by Elsevier B.V. on behalf of World journal of Acupuncture Moxibustion House.