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RNAi-mediated knockdown of RBPJ gene inhibits the growth of human breast cancer cells 期刊论文

编号：

509df1eb-22e4-4f4f-b149-01be64971824
作者：

Liu, Yuanxia(刘元霞)#*^[1]Weng, Hongbo^[2];
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY ISSN：1936-2625 2016 年 9 卷 2 期 (1249 - 1257)
收录：
关键词：

shRNA RBPJ proliferation MCF-7 breast cancer
摘要：

The Notch signaling pathway has been implicated in tumor growth in a number of different human tissues, including the colon, liver, and breasts. Regulation of this pathway in breast tissue has been investigated through several different methods with limited success. This study explored the efficacy of short hairpin RNA (shRNA) in modulating Notch signaling through its downstream transcription factor RBPJ in the human breast cancer cell line MCF-7. In this cell line, shRNA delivery through a lentivirus vector effectively downregulated RBPJ expression and protein levels. Importantly, overall cell proliferation was significantly reduced, and there was an increase in p21 expression and decreases in the expression of CDK2, Hes1, bcl-2, and SKP2. Together, these data suggest that shRNA knockdown of RBPJ in the Notch signaling pathway could be a novel therapeutic approach to treating human breast cancer.
推荐引用方式
GB/T 7714：

Liu Yuanxia,Weng Hongbo, et al. RNAi-mediated knockdown of RBPJ gene inhibits the growth of human breast cancer cells [J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2016,9(2):1249-1257.
APA：

Liu Yuanxia,Weng Hongbo.(2016).RNAi-mediated knockdown of RBPJ gene inhibits the growth of human breast cancer cells .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,9(2):1249-1257.
MLA：

Liu Yuanxia, et al. "RNAi-mediated knockdown of RBPJ gene inhibits the growth of human breast cancer cells" .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 9,2(2016):1249-1257.

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