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Structural elucidation of in vitro metabolites of bavachinin in rat liver microsomes by LC-ESI-MSn and chemical synthesis 期刊论文

编号：

4f7eec59-62dd-4371-9396-e6ef5d00fb35
作者：

Xie, Fan#^[1]Du, Guoxin^[1];Ma, Shunan^[1];Li, Yiming(李医明)^[1]Wang, Rui(王瑞)*^[1]Guo, Fujiang(郭夫江)*^[1]
语种：

英文
期刊：

XENOBIOTICA ISSN：0049-8254 2016 年 46 卷 4 期 (296 - 306)
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关键词：

Bavachinin chemical synthesis in vitro metabolism mass spectrometry rat liver microsomes
摘要：

Bavachinin isolated from Psoralea corylifolia has various activities, such as antimicrobial, antiallergic, antitumor and so on. Our previous study showed that natural bavachinin exhibits peroxisome proliferator-activated receptor gamma-agonist activity.
In vitro studies on bavachinin metabolism were conducted using rat liver microsomes incubated at 37 degrees C for 60 min.
Structures of eight metabolites of the incubation mixtures were cautiously characterized using electrospray tandem mass spectra and three synthetic compounds. The results indicated that eight metabolites of bavachinin were biotransformed mainly through oxidation.
The metabolic pathways of bavachinin were elucidated in vitro. These results contribute to the understanding of bavachinin's in vivo metabolism.
推荐引用方式
GB/T 7714：

Xie Fan,Du Guoxin,Ma Shunan, et al. Structural elucidation of in vitro metabolites of bavachinin in rat liver microsomes by LC-ESI-MSn and chemical synthesis [J].XENOBIOTICA,2016,46(4):296-306.
APA：

Xie Fan,Du Guoxin,Ma Shunan,Li Yiming,&Guo Fujiang.(2016).Structural elucidation of in vitro metabolites of bavachinin in rat liver microsomes by LC-ESI-MSn and chemical synthesis .XENOBIOTICA,46(4):296-306.
MLA：

Xie Fan, et al. "Structural elucidation of in vitro metabolites of bavachinin in rat liver microsomes by LC-ESI-MSn and chemical synthesis" .XENOBIOTICA 46,4(2016):296-306.
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