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FoxO3a pathway 期刊论文

编号：

4dadd2c7-20a5-4070-bf74-b116cfa7a5f0
作者：

Yang, Cheng#^[1,2,8]Cao, Ye#^[3,4]Zhang, Yi^[2];Li, Long^[1,2];Xu, Ming^[1,2];Long, Yaqiu^[5];Rong, Ruiming*^[1,2,6]Zhu, Tongyu*^[1,2,7]
语种：

英文
期刊：

Journal of Translational Medicine ISSN：1479-5876 2015 年 13 卷 ; NOV 10
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关键词：

Cyclic helix B peptide Renal ischemia reperfusion injury Fibrosis Akt FoxO3
摘要：

Renal fibrosis is a main cause of end-stage renal disease. Clinically, there is no beneficial treatment that can effectively reverse the progressive loss of renal function. We recently synthesized a novel proteolysis-resistant cyclic helix B peptide (CHBP) that exhibits promising renoprotective effects. In this study, we evaluated the effect of CHBP on renal fibrosis in an in vivo ischemia reperfusion injury (IRI) model and in vitro TGF-beta-stimulated tubular epithelial cells (TCMK-1 and HK-2) model. In the IRI in vivo model, mice were randomly divided into sham (sham operation), IR and IR + CHBP groups (n = 6). CHBP (8 nmol/kg) was administered intraperitoneally at the onset of reperfusion, and renal fibrosis was evaluated at 12 weeks post-reperfusion. Our results showed that CHBP markedly attenuated the IRI-induced deposition of collagen I and vimentin. In the in vitro model, CHBP reversed the TGF-beta-induced down-regulation of E-cadherin and up-regulation of alpha-SMA and vimentin. Furthermore, CHBP inhibited the phosphorylation of Akt and Forkhead box O 3a (FoxO3a), whose anti-fibrotic effect could be reversed by the 3-phosphoinositide-dependent kinase-1 (PI3K) inhibitor wortmannin as well as FoxO3a siRNA. These findings demonstrate that CHBP attenuates renal fibrosis and the epithelial-mesenchymal transition of tubular cells, possibly through suppression of the PI3K/Akt pathway and thereby the inhibition FoxO3a activity.
推荐引用方式
GB/T 7714：

Yang Cheng,Cao Ye,Zhang Yi, et al. Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway [J].Journal of Translational Medicine,2015,13.
APA：

Yang Cheng,Cao Ye,Zhang Yi,Li Long,&Zhu Tongyu.(2015).Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway .Journal of Translational Medicine,13.
MLA：

Yang Cheng, et al. "Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway" .Journal of Translational Medicine 13(2015).
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