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The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis 期刊论文

编号：

4982df50-da5b-4cf5-a029-0df5726b6e39
作者：

Lin, YiYuan^[1];Cheng, YuJung^[2];Hu, Jun(胡军)^[3]Chu, LiXi^[3];Shyu, WoeiCherng^[4,5,6];Kao, ChungLan^[7,8];Lin, TzerBin^[9,10,11];Kuo, ChiaHua^[2,12];Yang, AiLun#^[12]Lee, ShinDa#*^{[1,2,3,11,13]}
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ISSN：1422-0067 2016 年 17 卷 12 期 ; DEC
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关键词：

menopausal hypertension heart caspase cell death
摘要：

To investigate whether the coexistence of hypertension and ovariectomy will increase cardiac Fas receptor and mitochondrial-dependent apoptotic pathways, histopathological analysis, the TUNEL assay and Western blotting were performed on the excised hearts from three groups of female spontaneously hypertensive rats (SHR), which were divided into a sham-operated group (SHR-Sham), bilaterally ovariectomized group (SHR-OVX) and normotensive Wistar Kyoto rats (WKY). Compared with the WKY group, the SHR-Sham group exhibited decreased protein levels of ER alpha, ER beta, p-Akt/Akt, Bcl-2, Bcl-xL and p-Bad and decreased further in the SHR-OVX group, as well as protein levels of t-Bid, Bak, Bad, Bax, cytochrome c, activated caspase-9 and activated caspase-3 (mitochondria-dependent apoptosis) increased in the SHR-Sham group and increased further in the SHR-OVX group. Compared with the WKY group, protein levels of Fas ligand, TNF-alpha, Fas death receptors, TNFR1, FADD and activated caspase-8 (Fas receptor-dependent apoptosis) increased in the SHR-Sham group, but did not increase in the SHR-OVX group, except Fas ligand and TNF-alpha. The coexistence of hypertension and ovariectomy attenuated the estrogen receptor survival pathway and appeared to additively increase the cardiac mitochondria-dependent, but not the Fas receptor-dependent apoptosis pathway, which might provide one possible mechanism for the development of cardiac abnormalities in hypertensive postmenopausal women.
推荐引用方式
GB/T 7714：

Lin Yi-Yuan,Cheng Yu-Jung,Hu Jun, et al. The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis [J].INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(12).
APA：

Lin Yi-Yuan,Cheng Yu-Jung,Hu Jun,Chu Li-Xi,&Lee Shin-Da.(2016).The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(12).
MLA：

Lin Yi-Yuan, et al. "The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis" .INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17,12(2016).
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