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Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome 期刊论文

编号：

4828845d-d9dc-4405-86ae-61d97c8f9ddd
作者：

Ji, Qing(季青)#^[1,2]Wang, Wenhai#^[3]Luo, Yunquan(罗运权)#^[4]Cai, Feifei(蔡菲菲)^[1]Lu, Yiyu(陆奕宇)^[1]Deng, Wanli(邓皖利)^[2]Li, Qi(李琦)*^[2]Su, Shibing(苏式兵)*^[1]
语种：

英文
期刊：

ONCOTARGET ISSN：1949-2553 2017 年 8 卷 61 期 (103223 - 103235) ; NOV 28
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关键词：

systems biology proteomics traditional Chinese medicine colorectal cancer liver cancer
摘要：

Systems biology and bioinformatics provide the feasibility for the basic research associated with "same traditional Chinese medicine (TCM) syndrome in different diseases". In this study, the plasma proteins in postoperative colorectal (PCC) and postoperative liver cancer (PLC) patients with YDLKS (Yin deficiency of liver-kidney syndrome) were screened out using iTRAQ combined with LC-MS/MS technology. The results demonstrated that, KNG1, AMBP, SERPING1, etc, were all differentially expressed in both PCC and PLC patients with YDLKS, and associated closely with complement and coagulation cascades pathway. C7 and C2 were another two representative factors involving in former pathway. Further validation showed that, the C7 levels were increased significantly in PLC (P < 0.05) and PCC (P < 0.05) with YDLKS group compared to those of NS (no obvious TCM syndromes) group. The AMBP levels were down-regulated significantly in PLC with YDLKS group compared to those of PCC with YDLKS group (P < 0.05). The significant differences of SERPING1 levels (and C2 levels) were shown between YDLKS and NS in PCC (P < 0.01). There were also significant differences of C2 levels between PCC and PLC patients with YDLKS (P < 0.05). Moreover, significant differences of C2 levels were also found between PLC and PCC patients with YDLKS (P < 0.01). ROC curves indicated that, C7 and SERPING1 independently had a potential diagnostic value in distinguishing YDLKS from NS in PLC and PCC, providing the evidences for the material basis of "same TCM syndrome in different diseases" in PCC and PLC patients with YDLKS.
推荐引用方式
GB/T 7714：

Ji Qing,Wang Wenhai,Luo Yunquan, et al. Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome [J].ONCOTARGET,2017,8(61):103223-103235.
APA：

Ji Qing,Wang Wenhai,Luo Yunquan,Cai Feifei,&Su Shibing.(2017).Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome .ONCOTARGET,8(61):103223-103235.
MLA：

Ji Qing, et al. "Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome" .ONCOTARGET 8,61(2017):103223-103235.
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