首页 / 院系成果 / 成果详情页

Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues 期刊论文

编号：

47702ea7-1d97-42a9-b537-909568eca076
作者：

Tong, Bei#^[1]Dou, Yannong#^[1]Wang, Ting^[1];Yu, Juntao^[1];Wu, Xin^[1];Lu, Qian^[1];Chou, Guixin(侴桂新)^[2]Wang, Zhengtao(王峥涛)^[2]Kong, Lingyi^[3];Dai, Yue*^[1]Xia, Yufeng*^[1]
语种：

英文
期刊：

TOXICOLOGY AND APPLIED PHARMACOLOGY ISSN：0041-008X 2015 年 282 卷 1 期 (90 - 99) ; JAN 1
收录：
关键词：

Norisoboldine Regulatory T cell Th17 cell CIA Gut-associated lymphoid tissues
摘要：

Norisoboldine (NOR), the main active ingredient of the dry root of Lindera aggregata, was previously proven to have substantial therapeutic effects on collagen-induced arthritis (CIA) in mice by oral administration. However, it exhibited a very poor bioavailability in normal rats. The pharmacokinetic-pharmacodynamics disconnection attracts us to explore its anti-arthritic mechanism in more detail. In this study, NOR, administered orally, markedly attenuated the pathological changes in CIA rats, which was accompanied by the down-regulation of proinflammatory cytokines and the up-regulation of anti-inflammatory cytokine IL-10. Pharmacokinetic studies demonstrated that the plasma concentration of NOR was moderately elevated in CIA rats compared with normal rats, but it was still far lower than the minimal effective concentration required for inhibiting the proliferation and activation of T lymphocytes in vitro. Interestingly, NOR was shown to regulate the balance between Th17 and regulatory T (Treg) cells in the intestinal lymph nodes more strikingly than in other tissues. It could increase the expression of Foxp3 mRNA in both gut and joints, and markedly up-regulate the number of integrin alpha 4 beta 7 (a marker of gut source)-positive Foxp3(+) cells in the joints of CIA rats. These results suggest that the gut might be the primary action site of NOR, and NOR exerts anti-arthritis effect through regulating the balance between Th17 and Treg cells in intestinal lymph nodes and yielding a trafficking of lymphocytes (especially Treg cells) from the gut to joint. The findings of the present study also provide a plausible explanation for the anti-arthritic effects of poorly absorbed compounds like NOR. (C) 2014 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Tong Bei,Dou Yannong,Wang Ting, et al. Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues [J].TOXICOLOGY AND APPLIED PHARMACOLOGY,2015,282(1):90-99.
APA：

Tong Bei,Dou Yannong,Wang Ting,Yu Juntao,&Xia Yufeng.(2015).Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues .TOXICOLOGY AND APPLIED PHARMACOLOGY,282(1):90-99.
MLA：

Tong Bei, et al. "Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues" .TOXICOLOGY AND APPLIED PHARMACOLOGY 282,1(2015):90-99.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：42  下载次数：0

分享到：

浏览次数：42

下载次数：0

打印次数：0