The objective of this study is to investigate the antiviral, anti-inflammatory, and antioxidant effects of the ethanol extract of Mentha piperita L. leaves (MPE). M. piperita L. leaves were extracted by reflux with ethanol. Total phenolic acid and total flavonoid content were determined. The antiviral activity of MPE against the respiratory syncytial virus (RSV) and the anti-inflammatory activity were evaluated in vitro. The levels of key pre-inflammatory mediators and cytokines including nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, and prostaglandin E2 (PGE2) were determined. The antioxidant activities were also evaluated using a colorimetry method. MPE contained high levels of phenolic acid and flavonoid, showed antiviral activity against RSV with a high selectivity index, and significantly decreased the production of NO, TNF-alpha, IL-6, and PGE2 in lipopolysaccharide-stimulated RAW 264.7 cells. Meanwhile, MPE showed potential free-radical scavenging activities. These results indicate that Mentha piperita L. might be a good source of medicinal plants.
[1]Jilin Agr Sci & Technol Coll, Tradit Chinese Med Dept, Changchun 132101, Jilin, Peoples R China.
[2]Jilin Agr Univ, Minist Educ, Bioreactor & Drug Dev Res Ctr, Changchun 130118, Jilin, Peoples R China.
[3]Shanghai Univ TCM, Longhua Hosp, 725 Wanping South Rd, Shanghai 200032, Peoples R China.
[4]Shanghai Fengxian Dist Cent Hosp, Shanghai 201499, Peoples R China.
[5]Univ Minnesota, 210 Borlaug Hall,1991 Upper Buford Circle St Paul, Minneapolis, MN 55108 USA.
(8.0+极速模式)