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Mucosal transfer of wheat germ agglutinin modified lipid-polymer hybrid nanoparticles for oral delivery of oridonin 期刊论文

编号：

4399d4ae-f96a-4eaf-a995-623ec2c3c527
作者：

Liu, Ying(刘颖)#^[1]Liu, Jinguang#^[1]Liang, Jun^[1];Zhang, Meiying^[1];Li, Zhe^[1];Wang, Zhi(王志)^[1]Dang, Beilei^[1];Feng, Nianping(冯年平)*^[1]
语种：

英文
期刊：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE ISSN：1549-9634 2017 年 13 卷 7 期 (2219 - 2229) ; OCT
收录：
关键词：

Wheat germ agglutinin-modified lipid-polymer hybrid nanoparticles Mucus diffusion Bioavailability Antitumor effect
摘要：

Wheat germ agglutinin-modified lipid-polymer hybrid nanoparticles (WGA-LPNs) promote cellular uptake after oral delivery via receptor-mediated endocytosis and bioadhesion. Understanding the mucosal transport of WGA-LPNs would help to improve bioavailability and ensure therapeutic efficacy. In this study, WGA-LPNs interacted with mucin, forming larger agglomerates with intact core-shell structure. The interaction of WGA-LPNs with mucin improved enterocyte endocytosis in Caco-2 cells. An in situ intestinal diffusion study in mice confirmed that WGA-LPNs reached enterocytes and underwent endocytosis, despite interference from mucin. Importantly, oral bioavailability of oridonin-loaded WGA-LPNs increased by 1.96-fold compared with that of LPNs. Furthermore, oral administration of WGA-LPNs inhibited tumor growth in HepG2 xenograft nude mice. In addition to elucidating interactions between WGA-LPNs and mucin, these results indicated that WGA-LPNs might act as promising nanocarriers for oral delivery of drugs. (C) 2017 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Liu Ying,Liu Jinguang,Liang Jun, et al. Mucosal transfer of wheat germ agglutinin modified lipid-polymer hybrid nanoparticles for oral delivery of oridonin [J].NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2017,13(7):2219-2229.
APA：

Liu Ying,Liu Jinguang,Liang Jun,Zhang Meiying,&Feng Nianping.(2017).Mucosal transfer of wheat germ agglutinin modified lipid-polymer hybrid nanoparticles for oral delivery of oridonin .NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13(7):2219-2229.
MLA：

Liu Ying, et al. "Mucosal transfer of wheat germ agglutinin modified lipid-polymer hybrid nanoparticles for oral delivery of oridonin" .NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13,7(2017):2219-2229.
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