首页 / 院系成果 / 成果详情页

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats 期刊论文

编号：

42776da4-0ae7-432e-bdec-538eeb77b254
作者：

Wang, Zhenwei(王振伟)#^[1]Yang, Wenlan#^[2]Yang, Peilan(杨佩兰)*^[1]Gao, Beilan*^[3]Luo, Lei^[4];
语种：

英文
期刊：

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE ISSN：1472-6882 2016 年 16 卷 ; NOV 10
收录：
关键词：

Radix Stemonae Chronic obstructive pulmonary disease Pathology Inflammatory mediators
摘要：

Background: Chronic obstructive pulmonary disease (COPD) is a common and frequently occurring respiratory disease. At present, western medicine treatment of COPD mainly focuses on symptomatic treatment. Using Chinese medicines or integrated Chinese and Western medicines to treat stable COPD has significant efficacy. In this study, we aimed to observe the effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats and explore its possible mechanism.
Methods: SD rats were randomized into blank group, COPD model group and Radix Stemonae group, 10 cases in each group. Rats were fed for 112 days. Before the rats were sacrificed, lung function of the animals was tested. The right lower lung was fixed for morphologic observation. The inflammatory mediators in serum were determined using enzyme-linked immuno sorbent assay.
Results: Body weight of animals in the model group was significantly decreased compared with blank group (P < 0.05). After gavage therapy with Radix Stemonae, body weight was significantly increased (P < 0.05). Compared with the blank group, pulmonary functions of rats in the model group were significantly abnormal (P < 0.05), while in Radix Stemonae group, these indicators turned much better than model group (P < 0.05). As for pathological changes in lungs, airway inflammation in the model group was aggravated. In the Radix Stemonae group, inflammation and emphysema were much milder. The concentrations of TNF-alpha, IL-8 and LTB4 in both model group and Radix Stemonae group were increased significantly (P < 0.05). But the levels in Radix Stemonae group were decreased significantly than model group (P < 0.05).
Conclusion: Radix Stemonae concentrated decoction may mitigate and improve airway rebuilding in the lungs of COPD rats by inhibiting the release of inflammatory mediators.
推荐引用方式
GB/T 7714：

Wang Zhenwei,Yang Wenlan,Yang Peilan, et al. Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats [J].BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016,16.
APA：

Wang Zhenwei,Yang Wenlan,Yang Peilan,Gao Beilan,&Luo Lei.(2016).Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats .BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,16.
MLA：

Wang Zhenwei, et al. "Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats" .BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 16(2016).
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：38  下载次数：0

分享到：

浏览次数：38

下载次数：0

打印次数：0